Objective Brown fat activation attenuates atherosclerosis development by accelerating triglyceride-rich lipoprotein turnover and/or stimulation of reverse cholesterol transport via the SRB1 (scavenger receptor class B type 1). The aim of this study was to investigate the specific role of hepatic SRB1 ...
we examined whether RNF128 was involved in the increased lipid influx or inadequate cholesterol outflow. First, we performed an uptake assay of oxLDL labeled using a red fluorescent probe (Dil-oxLDL), which suggested that the fluorescence intensity of Dil-oxLDL ...
SRB1 is mostly expressed in the liver, where it takes part in reverse cholesterol transport (Vergeer et al., 2011). It is also known that SRB1 promotes the efflux of cholesterol from macrophages to HDL. On the other hand, the receptor activity is not unambiguous. To date, it was ...
reverse cholesterol transportBackground: Plasma HDL cholesterol levels are inversely related to cardiovascular disease, which is the leading cause of death worldwide. This study investigated the effect of an algae infusion, ProAlgaZyme (PAZ), and its subfractions (P1, P2, P3, P4) on plasma ...
DG also increased intestinal SRB1 and CES-1, inhibiting cholesterol absorption and promoting RCT. The expression levels of these receptors in the HDG group were higher than LDG and Sim groups. These data suggested that DG accelerated reverse cholesterol transport (RCT) and enhanced cholesterol ...
A two-fold increase in SRB1 expression indicates that P4 further augments the reverse cholesterol transport mechanism. Reduction of CETP expression (P4) is consistent with a decrease in the transfer of cholesteryl ester to LDL, further increasing the amount of cholesterol held as HDL particles....