Cloning of a gene (SR-A1), encoding for a new member of the human Ser/Arg-rich family of pre-mRNA splicing factors: overexpression in aggressive ovarian cancer - Scorilas, Kyriakopoulou, et al. - 2001 () Citation Context ...were over-expressed, while 4 of 5 down-regulated cases were...
PCR.Results:siRNAof80nmol/LshowedthestrongestinhibitionforthegeneexpressionofPCSK9.andox—LDL—inducedaccumula. tionofcholesterolandupregulationofCD36mRNAexpressioninTHP-1derivedmaerophagesdecreasedbyapplicationofPCSK9siR. NA(P<0.05).However,PCSK9siRNAcausednoefectonox—LDL-inducedupregulationofSR-A1mRNAandSR...
食管鳞癌组织的LncRNA-SRA1水平及临床意义
SREBP-1c is a transcription factor known to regulate the expression of the lipogenic gene. FAS plays an important role in diet-induced atherosclerosis. CD36, a member of the SR-B family, plays a significant role in macrophage binding and uptake of Ox-LDL. Therefore, the effect of RUT...
疾病领域得分 一眼洞穿机构专注的疾病领域 技术平台 公司药物应用最多的技术 靶点 公司最常开发的靶点 在研适应症 凝血因子Ⅶ缺乏症[+2] 非在研适应症- 最高研发阶段 靶点 原研机构 临床1期 首次获批国家/地区- 首次获批日期- 项与 睿智医药科技股份有限公司 相关的临床试验 ...
In the nucleus, activated GR can interact with the regulatory regions of responsive genes to alter the level of gene expression [16]. The aim of the present investigation was to study the role of the synthetic glucocorticoid dexamethasone in the regulation of ABCA1, ABCG1, and SR-BI. Here...
These results indicate that EZ could affect the transcription of the surface receptors SR-BI, NPC1L1, and ABCA1 via the downregulation of the gene expression of the nuclear receptors RARγ, RXRα, SREBP-1, SREBP-2, and LXRβ. TABLE 3. mRNA expression of various genes involved in vitamin...
Copilot će početi da generiše radnu verziju u skladu sa vašim unosom. Da biste otkazali proces generisanje, pritisnite kombinaciju tastera Shift+Tab i kliknite na dugme Zaustavi u dijalogu. Ako želite da promenite radnu verziju, u polju Sve što...
The role of ATP-binding-cassette-transporter-A1 (ABCA1) gene polymorphism on coronary artery disease risk. ATP-binding cassette transporter A1 (ABCA1) plays a pivotal role in intracellular cholesterol removal and exerts a protective effect against atherosclerosi... M Doosti,M Najafi,JZ Reza,......
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