In contrast to hyperkeratosis of orolaryngeal mucosa, where its risk factors and association with squamous neoplasia are well-studied, the prevalence and clinicopathological features of oesophageal hyperkeratosis are unknown. We reviewed prospectively 1845 oesophageal biopsies and found hyperkeratosis in 37...
Head and neck squamous cell carcinoma - Nasr, Khatri - 2000 () Citation Context ...nges like hyperkeratosis, epithelial hyperplasia and mild dysplasia (Ali et al., 2004, 2006). A higher incidence of head and neck cancer has been reported among khat chewers compared with nonchewers (=-=...
Squamous cell carcinoma of the skin (excluding lip and oral mucosa). J Am Acad Dermatol. 1992;26(3 Pt 2):467–84. Article PubMed CAS Google Scholar Kerr-Valentic MA, Samimi K, Rohlen BH, Agarwal JP, Rockwell WB. Marjolin’s ulcer: modern analysis of an ancient problem. Plast ...
Abnormal nuclear morphology is thesine qua nonof both LSIL and HSIL, but it is more pronounced with HSIL. Irregularities in the nuclei of HSIL cells are one of the most reliable diagnostic features of this lesion and reflect profound derangements in cellular function andgeneticinstability. Hy...
Hematoxylin-eosin-stained sections were examined. The biopsy specimen showed a cystic tumor arising from a dilated eccrine duct (Figure 4). The initially cuboidal ductal epithelium showed progressive squamoid changes with hyperkeratosis within an area of cystic dilatation. Lateral and deep, these squam...
Sixty formalin-fixed paraffin-embedded tissue blocks consisting of histopathologically diagnosed cases of normal mucosa (n = 10), OL (n = 14) hyperkeratosis with various grades of dysplasia, OSMF (n = 11), and OSCC (n = 25) were subjected to immunohistochemistry using α-SMA antibody for ...
Marked irregular acanthosis, focal hypergranulosis, and compact orthokeratosis with parakeratosis. Pathogenesis. It is generally assumed that the neural proliferation in prurigo nodularis is a secondary phenomenon due to chronic trauma by scratching. Still, it may be that the extreme pruritus is related...
Here, we show that those traits can be triggered by the RHO GTPase activator VAV2 in keratinocytes present in the skin and oral mucosa. VAV2 is also required to maintain those traits in hnSCC patient-derived cells. This function, which is both catalysis- and RHO GTPase-dependent, is ...
Precancerous lesions of the oral mucosa, especially those accompanied by moderate to severe dysplasia, contribute to the initiation of oral squamous cell carcinoma (OSCC). However, the cellular compositions and spatial organization of the precancerous st
Tylosis esophageal cancer, also known as Howel–Evans syndrome, is a rare familial cancer syndrome inherited in an autosomal dominant manner and characterized by hyperkeratosis of the palms or soles. People with this syndrome have a high risk of esophageal cancer.75 More than 90% of patients wi...