180,181Therefore, the suppressive or oncogenic functions of Notch in tumorigenesis have a contextual basis. According to a 2015 TCGA analysis, NOTCH1-3 is inactivated in 17% HPV+and 26% HPV-HNSCC.138The majority of these aberrations are found in NOTCH1, including nonsense mutations causing trun...
adenomatoid hyperplasiaretromolar areaminor salivary glandcase reportCarcinoma of the tongue is a common condition treated by oral and maxillofacial surgeons. The tongue is a complex anatomical site at the entrance of the oropharynx, bounded by the floor of mouth and lingual mandibular cortex; its ...
Simultaneous occurrence of a rare lymphoepithelial cyst and squamous cell carcinoma in the oral cavity Fabio,Wildson,Gurgel,... - 《Brazilian Journal of Otorhinolaryngology》 被引量: 7发表: 2011年 Simultaneous occurrence of adenoma, focal nodular hyperplasia, and hemangioma of the liver: Are they ...
Figure 4.7.Reflux esophagitis. This shows basal cell hyperplasia, separation of cell junctions (dilated intercellular spaces), and scattered intraepithelial eosinophils. These findings are not specific for reflux and can be seen in other types of esophageal injury. ...
The mucosa around the fistulas appeared normal otherwise, with no hyperplasia, erythema, or keratotic changes. The patient had a 14-year history of recurrent erythroleukoplakia (with microscopic dysplasia) on the left tongue that had been managed by surgical removal (scalpel and carbon dioxide ...
Yellow represents the hyperplasia/keratosis (HK) group, red represents the OSCC group and orange represents the epithelial dysplasia (ED) group. LDA Score > 2 was considered significant Full size image Bacteria related to the progression in the development from epithelial proliferation to cancer ...
Ten cases of oral fibroepithelial hyperplasia were selected as the control group. The expression of BMP-2/4 and BMPR-IA was analyzed by immunohistochemistry.ResultsIn the experimental group with metastasis, strong expression of BMP-2/4 was observed in most cases (71.4%), whereas BMPR-IA ...
Conditional deletion of Pten causes bronchiolar hyperplasia. Am J Respir Cell Mol Biol 2008; 38: 337–345. 33. Tompkins DH, Besnard V, Lange AW, Keiser AR, Wert SE, Bruno MD et al. Sox2 activates cell proliferation and differentiation in the respiratory epithelium. Am J Respir Cell Mol ...
The retrospective cohort study included formalin-fixed and paraffin-embedded samples of human oral mucosa (O.M., non-neoplastic oral samples diagnosed with fibrous hyperplasia, n = 50), premalignant lesions (P.L., oral leukoplakia, n = 50) and OSCCs (well differentiated OSCC, W.D....
Membrane expression was and reactive (including normal, hyperplasia, and scored on the basis of the intensity and complete- squamous metaplasia) and dysplastic (including ness of immunostaining, similar to Her2-Neu assess- dysplasia and carcinoma in situ). Finally, to deter- ment classification.14 ...