Cutaneous SCC (cSCC) is a common skin cancer characterized by the malignant proliferation of epidermal keratinocytes and it is classified as a keratinocyte carcinoma together with basal cell carcinoma [8]. It is distinguished into in situ (Bowen’s disease) and invasive form, and invasive cSCC is...
In time, this atypia may extend to the full thickness of the epidermis (AK3/squamous cell carcinoma in-situ) or beyond, culminating in invasive cutaneous squamous cell carcinoma (cuSCC). Ultraviolet radiation (UVR) is the main aetiological factor implicated in AK and cuSCC pathogenesis. ...
expression of nEGFR and markers of cell proliferation (Ki-67), cell cycle (mEGFR, p53, cyclin D1), and tumor stem cells (ABCG2) in 59 pathohistological samples of healthy oral mucosa, 50 oral premalignant changes (leukoplakia and erythroplakia), and 52 oral squamous cell carcinomas (...