Cutaneous squamous cell carcinoma (SCC) is an increasingly prevalent global health concern. Current diagnostic and surgical methods are reliable, but they require considerable resources and do not provide metabolomic insight. Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) ...
Tsai1,2 Cutaneous squamous cell carcinoma (cuSCC) comprises 15–20% of all skin cancers, accounting for over 700,000 cases in USA annually. Most cuSCC arise in association with a distinct precancerous lesion, the actinic keratosis (AK). To identify potential targets for molecularly targeted ...
Adenocarcinoma (ADC) and squamous cell carcinoma (SqCC) are the two predominant subtypes of non-small cell lung cancer (NSCLC) and are distinct in their histological, molecular and clinical presentation. However, metabolic signatures specific to individual NSCLC subtypes remain unknown. Here, we perfo...
Fascin is a globular actin cross-linking protein, which plays a major role in forming parallel actin bundles in cell protrusions and is found to be associated with tumor cell invasion and metastasis in various type of cancers including oral squamous cell carcinoma (OSCC). Previously, we have de...
Subsequent in situ detection of HPV mRNA using an RNAscope approach confirmed that early HPV gene expression was occurring in the majority of cases of HPV DNA-positive conjunctival in situ squamous cell carcinoma, with all of these cases occurring in the atopic group. Viral gene expression ...
6). All of them have previously been reported in ESCC and two other types of squamous cell carcinomas, head and neck squamous cell carcinomas (HNSCC) and lung squamous cell carcinomas (LUSCC) (Supplementary Data 4). To increase the statistical power to detect the driver mutations, we ...
Int J Cancer 76: 613 – 619 Lacey Jr JV, Frisch M, Brinton LA, Abbas FM, Barnes WA, Gravitt PE, Gren- berg MD, Greene SM, Hadjimichael OC, McGowan L, Mortel R, Schwartz PE, Zaino RJ, Hildesheim A (2001) Associations between smoking and adenocarcinomas and squamous cell carcinomas ...
FULL PAPER British Journal of Cancer (2014) 110, 479–488 | doi: 10.1038/bjc.2013.700 Keywords: slice cultures; personalised therapy; cancer; chemotherapy; resistance; chemosensitivity Slice cultures from head and neck squamous cell carcinoma: a novel test system for drug susceptibility and ...
2Department of Surgery, Medical Institute of Bioregulation, Kyushu University, Beppu, Japan BACKGROUND: Recently, PFTK1 was identified as a member of the cyclin-dependent kinase family; however, its expression and clinical significance in oesophageal squamous cell carcinoma (ESCC) have not been evalu...
To date, therapeutic strategies in vulvar squamous cell carcinoma (VSCC) are lacking molecular pathological information and targeted therapy hasn’t been approved in the treatment of VSCC, yet. Two etiological pathways are widely accepted: HPV induced vs. HPV independent, associated with chronic skin...