Squamous Cell Carcinoma Squamous cell carcinoma is a primary malignant lung neoplasm displaying features of squamous differentiation. Squamous cell carcinoma is the lung tumor most frequently associated with ci
Several clonal teratocarcinoma cell lines restricted to squamous cell differentiation have been established from a subculture of totipotential murine teratocarcinoma stem cells. These lines contain a continuum of cell types from less differentiated precursor cells to differentiated squamous cells. In ...
Targeted therapy has greatly improved both survival and prognosis of cancer patients. However, while therapeutic treatment of adenocarcinoma has been advanced greatly, progress in treatment of squamous cell carcinoma (SCC) has been slow and ineffective.
Squamous cell carcinoma (SCC) and adenocarcinoma (AC) are two main histological subtypes of solid cancer; however, SCCs are derived from different organs with similar morphologies, and it is challenging to distinguish the origin of metastatic SCCs. Here we report a deep proteomic analysis of 333 ...
Oral squamous cell carcinoma (OSCC) is a prevalent form of cancer globally. This disease is characterized by its complex genetic underpinnings, involving the intricate regulation of multiple genes. Genetic factors influence cellular processes such as growth, differentiation, and apoptosis of oral mucosal...
Abbreviations Basal cell carcinomas, BCC; Betacellulin, BTC; 2-bromopalmitate, 2-Bromo; Cluster of differentiation, CD; Cytochrome c oxidase IV, COX IV; Desmoglein 2, Dsg2; Early endosome antigen 1, EEA1; Epidermal growth factor receptor substrate 15, EPS15; Extracellular vesicle, EV; ...
Immune checkpoint blockade (ICB) approaches have changed the therapeutic landscape for many tumor types. However, half of cutaneous squamous cell carcinoma (cSCC) patients remain unresponsive or develop resistance. Here, we show that, during cSCC progres
cell carcinoma (OSCC) exhibited Smad4 loss [67]. We examined Smad4 mRNA expression in human HNSCC, and found 86% of tumors and 67% of adjacent non-malignant mucosa had > 50% Smad4 reduction. Smad4 protein staining is consistent with mRNA level. In contrast to the strong Smad4 staining...
Small cell neuroendocrine carcinoma of the ampulla of Vater with foci of squamous differentiation: a case report. J Hepatobiliary Pancreat Surg 2004; 11:56-60. [PMID: 15747032]Gen;Sugawara;Akihiro;Yamaguchi;Masatoshi;Isogai;Yoshio;Watanabe;Yuji;Kaneoka;Masahiko;Suzuki.Small cell neuroendocrine ...
Abbreviations FAM3C: Family with sequence similarity 3, member C; ILEI: Interleukin-like epithelial-mesenchymal transition inducer; FAM3: Family with sequence similarity 3; EC: Esophageal cancer; ESCC: Esophageal squamous cell carcinoma; OS: Overall survival; TNM: Tumor-node-metastasis; RNA-Seq: ...