We also take a look at the Mark Patton – Nightmare On Elm Street 2: Freddys Revenge documentary; Scream, Queen! My Nightmare On Elm Street! Scream, Queen! My Nightmare On Elm Street on Shudder or pick a copy of the DVD over on amazon here: https://amzn.to/37OOyQq Be sure to ...
The Phox and Bem1 (PB1) domain of p62, interacting with PB1-containing proteins, such as p62, neighbor of the BRCA1 gene 1 (NBR1), atypical protein kinase Cζ (aPKCζ), or mitogen-activated protein kinase kinase kinase 3 (MEKK3) to form homo-oligomers or hetero-oligomers. The ...
We thank Kenneth H Brown, Jean Bosco Ouedraogo, Steve Vosti and André Briend for advice in trial conceptualization, Mark Manary for making a site monitoring visit, and Lindsay Allen for helping to define the SQ-LNS formulation and for input at various stages. Funding Supported in part by a ...
Previous studies showed that purified full-length p62 can also form helical filaments7,8. The existence of these assembly structures inside of cells, however, had not been demonstrated. Therefore, we used the CLEM technique to identify and visualize the ultrastructural organization of p62 found in ...
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Could be amusing if somebody rounded up old 35mm sensors (say like from the 5D mark I) for this. It would still be a substantial upgrade, right? LikeJul 17, 2017permalink Hide replies Reply tinternaut I've written before that something like one of these would be nice to have when ...
Lamark, E. Sjøttem, K.B. Larsen, J.A. Awuh, A. Øvervatn, M. McMahon, J.D. Hayes, T. Johansen p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription J. Biol. Chem., ...
Full size image We next examined the role of p62ZZin selective autophagy using cells under misfolded protein stress, induced by proteasome inhibitor MG132. Immunoblotting analysis showed that p62-/- MEFs failed to properly induce the lipidation of LC3 as compared with +/+ MEFs when the cells ...
(Fig. 2 A and not depicted). This is also the case with the D69A mutant, which abrogates PB1 domain–mediated polymerization of p62 (Fig. 2 A; Lamark et al., 2003). This strongly indicates that the PB1 domain–mediated polymerization of p62 is essential for the formation of ...
Full size image We next examined the role of p62ZZin selective autophagy using cells under misfolded protein stress, induced by proteasome inhibitor MG132. Immunoblotting analysis showed that p62-/- MEFs failed to properly induce the lipidation of LC3 as compared with +/+ MEFs when the cells ...