“什么?你让我七天内搞定老婆和孩子?孩子还得就读名门学校?”估计黄昏同志心里顿时开始复读MMP。仅仅喷了咖啡撕了情报(报纸)的他顿时冷静下来,因为这是作为间谍的素养。 间谍黄昏 虽然是荒诞可笑的理由,但是现世的政治斗争理由难道充分吗? 缘由是组织派给黄昏一个任务“枭”,需要靠孩子就读名门学校参加活动才能接近目...
However, the mechanisms responsible for p53 regulation by p300 and SIRT1 are still poorly understood. Here we identify the nucleosome assembly protein TSPY-Like 2 (TSPYL2, also known as TSPX, DENTT, and CDA1) as a novel regulator of SIRT1 and p300 function. We demonstrate that, upon ...
Cullin-RING E3 ubiquitin ligases (CRLs), the largest family of multi-subunit E3 ubiquitin ligases in eukaryotic cells, represent core cellular machinery for executing protein degradation and maintaining proteostasis. Here, we asked what roles Cullin proteins play in human mesenchymal stem cell (hMSC)...
This group of SET/NAP domain-containing proteins has been designated as the TSPY/NAP/SET (TNS) family, whose members participate in numerous physiological functions, including cell cycle regulation, signaling transduction, and cell differentiation Acknowledgments This study was supported by a VA ...
I love that it’s something I can play with my family, friends or just on my own. Every time I step on a course, I get a huge smile, feel relaxed and get into my happy zone. Exploring courses all over the world is probably my favourite part. ...
My wife has some family and friends that work at Boeing. A good friend of mine retied from Boeing and moved to Montana to golf and fish. Last year he moved to AZ... now mostly golfs! Slight shank 1 Quote “We don’t stop playing the game because we get old; we get old ...
Major members of this protein family include SET, NAP-1, TSPY, differentially expressed nucleolar TGF-β1 target (DENTT) [10, 11]/cell division autoantigen-1 (CDA1) [12]/TSPX [13]. SET was initially identified in a patient with acute undifferentiated leukemia, who harbored an intra...
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