参考外显子组整合(Exome Aggregation Consortium,ExAC)数据库、千人数据库、基因组聚合数据库等正常人群数据库进行变异过滤,使用单核苷酸多态性数据库、人类遗传疾病在线遗传目录(Online Mendelian Inheritance in Man,OMIM)、人类基因突变数据...
In this study, pan-cancer genetic analyses by using TCGA cohorts, more frequent mutation events were found in cytoskeleton-related genes as compared to total annotated genes, especially in cancers derived from hollow organs. High-dimensional analysis of molecular alterations in cancer (HD-MAC) ...
To test if other FLT3 abnormalities might be involved in BCR-ABL–negative CML, we analyzed 40 cases and found that 2 (5%) were positive for the FLT3 ITD, but mutation of residue D835 was not observed. SPTBN1-FLT3 transforms Ba/F3 cells to growth factor independence To test if SPTBN1-...