Crosstalk between the type 1 interferon and nuclear factor kappa B pathways confers resistance to a lethal virus infection. Cell Host Microbe 13, 701–710 (2013). Article CAS PubMed PubMed Central Google Scholar Haka, A. S. et al. Macrophages create an acidic extracellular hydrolytic ...
Plasma and isolated lipoproteins were collected in each phase of the study and subsequently analyzed to assess lipid profile, CoQ10 levels, ORAC assay, resistance of lipoproteins to peroxidation and paroxonase 1 activity. Plasma CoQ10 levels significantly increased with the 20 mg (+73%) and 40 ...
PCa cells are highly dependent upon the microenvironment where cytokines and contact with stromal cells promote cell activation and proliferation as well as resistance to spontaneous and drug-mediated apoptosis. Like many oncogenic and growth related pathways, many of these microenvironment-activated pathway...
Because the majority of TNBC cells do not possess a specific target, it is relatively difficult to find an effectively available treatment, and generally has an adverse prognosis with a high risk of recurrence and metastasis and resistance to conventional therapy. MDA-MB-231 cells, a model TNBC...
metabolism rewiring is associated with partial epithelial-to-mesenchymal transition (EMT). In particular, we documented how autocrine TGF-β2 signaling favors the formation of lipid droplets (LD) that further act as energy stores to support anoikis resistance, local invasiveness and distant metastatic ...
Indeed, the properties underpinning prion-like mechanisms—such as stable, self-propagating aggregates, cell-to-cell transmission, the existence of conformational strains, selective cellular and regional vulnerability, stability and resistance to inactivation, and the toxicity of oligomers—are essential ...