1. Pan, J. et al. A hierarchical combination of factors shapes the genome-widetopographyof yeast meioticrecombinationinitiation.Cell144, 719–731 (2011). 2. Keeney, S., Giroux, C. N. & Kleckner, N. Meiosis-specific DNA double-strand breaks are catalyzed by Spo11, a member of a widely...
Keeney S (2008) Spo11 and the formation of DNA double-strand breaks in meiosis. Genome Dyn Stab 2:81–123Keeney, S. ( 2008 ) Spo11 and the formation of DNA double-strand breaks in meiosis . Genome Dyn. Stab. 2 , 81 – 123 ....
1. Pan, J. et al. A hierarchical combination of factors shapes the genome-wide topography of yeast meiotic recombination initiation. Cell 144, 719–731 (2011). 2. Keeney, S., Giroux, C. N. & Kleckner, N. Meiosis-specific DNA double-strand breaks are catalyzed by Spo11, a member of ...
Genetic recombination arises during meiosis through the repair of DNA double-strand breaks (DSBs) that are created by Spo11, a topoisomerase-like protein1,2. Spo11 DSBs form preferentially in nucleosome-depleted regions termed hotspots3,4, yet how Spo11 engages with its DNA substrate to catalyse...
Meiosis-Specific DNA Double-Strand Breaks Are Catalyzed by Spo11, a Member of a Widely Conserved Protein Family Author links open overlay panelScott Keeney 1, Craig N Giroux 2, Nancy Kleckner 1Show more Add to Mendeley Share Cite https://doi.org/10.1016/S0092-8674(00)81876-0Get rights ...
CAS号: 英文名: Meiosis recombinant protein SPO11 antibody 英文别名: Rabbit Anti-SPO11 antibody 中文名: 减数分裂重组蛋白SPO11抗体 中文别名: 减数分裂重组蛋白SPO11抗体 CBNumber: CB55521341 分子式: 分子量: 0 MOL File: Mol file 化学性质安全信息用途供应商14 ...
configuration, and cluster in domains along the chromosome. Expression of the Spo11 is detected mainly in the testis, in agreement with its predicted function in the initiation of meiotic recombination. Disruption of Spo11 leads to severe gonadal abnormalities from defective meiosis and results in ...
Meiotic processes are potentially dangerous to genome stability and could be disastrous if activated in proliferative cells. Here we show that two key meiosis-defining proteins, the topoisomerase Spo11 (which forms double-strand breaks) and the meiotic c
We investigated the role in meiosis of the three kinases [ATM (ataxia telangiectasia mutated), ATR (ataxia-telangiectasia- and Rad-3-related) and DNA-PKcs (DNA-dependent-protein-kinase catalytic subunit)] known to phosphorylate H2AX in mitotic cells. We found that DNA-PKcs can be ruled out ...
During meiosis in yeast, a meiotic recombination protein is covalently-linked to the 5' end of DSBs and is essential for the formation of DSBs. SPO11 is similar in sequence and conserved features to the yeast meiotic recombination protein. It belongs to the TOP6A protein family. Meiotic ...