spiny projection neuronThe principal neurons of the striatum, the GABAergic spiny projection neurons (SPNs), are connected by local axonal collateral synapses, but the extent of axosomatic synapses between striatal SPNs is unknown. If extensively present, somatic innervation would indicate potential ...
While D1-SPN average population activity at grooming onset was not different inSapap3-WT vs. -KO mice (Fig.2d–f), it is possible that differential recruitment of D1-SPNs within these functional clusters is associated with elevated grooming. We found thatSapap3-KOs had lower proportions of...
the dorsal and ventral striatum contain populations of spiny projection neurons, which make up 95% of the neurons within the striatum.SPNs are canonically categorized into those that express the D1‐type dopamine receptor (D1SPNs) and those that express the D2‐type dopamine receptor (D2SPNs)...
Dynamic postnatal development of the cellular and circuit properties of striatal D1 and D2 spiny projection neuronsKey points Imbalances in the activity of the D1‐expressing direct pathway and D2‐expressing indirect pathway striatal projection neurons (SPNs) are thought to contribute to many basal...
Striatal spiny neurons (SPNs) transition from a hyperpolarized 'down state' to a sustained depolarized 'up state' to regulate action selection. The authors report that glutamate uncaging on proximal dendritic spines of SPNs evokes somatic up states that
Using intracellular recordingtechniques,wemeasuredsubthresholdinputstospinyprojectionneurons(SPNs)inurethane-anesthetizedrats.Contralateral whole-field light flashes evoked weak membrane potential responses in approximately two-thirds of neurons. However, after local disinhibitory injections of the GABA A ...
These populations of direct and indirect pathway-projecting spiny projection neurons (SPNs) have classically been thought to promote or suppress actions, respectively, leading to a long-held hypothesis that increased output of direct relative to indirect pathway promotes compulsive behavior. Contrary to ...
NEURONSNEURAL transmissionGLUTAMATE receptorsSYNAPSESGABADOPAMINE receptorsCOMPUTATIONAL neuroscienceSynaptic transmission mediated by GABAA receptors (GABAARs) in adult, principal striatal spiny projection neurons (SPNs) can suppress ongoing spiking, but its effect on synaptic integration ...
Previous studies have also found putative autapses in principal spiny projection neurons (SPNs) in the striatum. However, it remains unclear whether these neurons indeed form physiologically functional autapses. We applied whole-cell recording in striatal slices and identified autaptic...
Striatal spiny projection neurons (SPNs) transform convergent excitatory corticostriatal inputs into an inhibitory signal that shapes basal ganglia output. This process is fine-tuned by striatal GABAergic interneurons (GINs), which receive overlapping cortical inputs and mediate rapid corticostriatal feed...