These populations of direct and indirect pathway-projecting spiny projection neurons (SPNs) have classically been thought to promote or suppress actions, respectively, leading to a long-held hypothesis that increased output of direct relative to indirect pathway promotes compulsive behavior. Contrary to ...
While D1-SPN average population activity at grooming onset was not different inSapap3-WT vs. -KO mice (Fig.2d–f), it is possible that differential recruitment of D1-SPNs within these functional clusters is associated with elevated grooming. We found thatSapap3-KOs had lower proportions of...
spiny projection neuronThe principal neurons of the striatum, the GABAergic spiny projection neurons (SPNs), are connected by local axonal collateral synapses, but the extent of axosomatic synapses between striatal SPNs is unknown. If extensively present, somatic innervation would indicate potential ...
Autapses selectively form in specific cell types in many brain regions.Previous studies have also found putative autapses in principal spiny projection neurons(SPNs)in the striatum.However,it remains unclear whether these neurons indeed form physiologically functional autapses.We applied whole-cell ...
However, little is known about the spatial gene expression patterns and heterogeneity of spiny projection neurons (SPNs) within somatotopic subregions. Here, we show that the cell adhesion molecule gene Cdh20, which encodes a Type II cadherin, is expressed in discrete subregions covering the inner...
Previous studies have also found putative autapses in principal spiny projection neurons (SPNs) in the striatum. However, it remains unclear whether these neurons indeed form physiologically functional autapses. We applied whole-cell recording in striatal slices and identified autaptic cells by the ...
Previous studies have also found putative autapses in principal spiny projection neurons (SPNs) in...Wang, XuanShu, ZhenfengHe, QuanshengZhang, XiaowenLi, LuozhengZhang, XiaoxueLi, LiangXiao, YujiePeng, BoGuo, FeifanSpringer Nature SingaporeNeuroscience Bulletin...
NEURONSNEURAL transmissionGLUTAMATE receptorsSYNAPSESGABADOPAMINE receptorsCOMPUTATIONAL neuroscienceSynaptic transmission mediated by GABAA receptors (GABAARs) in adult, principal striatal spiny projection neurons (SPNs) can suppress ongoing spiking, but its effect on synaptic integration ...
Striatal spiny projection neurons (SPNs) transform convergent excitatory corticostriatal inputs into an inhibitory signal that shapes basal ganglia output. This process is fine-tuned by striatal GABAergic interneurons (GINs), which receive overlapping cortical inputs and mediate rapid corticostriatal feed...
NEURONSKey points: Imbalances in the activity of the D1‐expressing direct pathway and D2‐expressing indirect pathway striatal projection neurons (SPNs) are thought to contribute to many basal ganglia disorders, including early‐onset neurodevelopmental disorders such as obsessive–compulsive disorder, ...