Genome editing in spinocerebellar ataxia type 3 cells improves Golgi apparatus structure Yanlin Wang Yunan Cheng Yuming Xu ResearchOpen Access09 Apr 2025Scientific Reports Volume: 15, P: 12106 Denervation of rectus capitis posterior minor as neglected factor in Chiari malformation type I revealed by do...
Spinocerebellar ataxia type 3Astragaloside IVOxidative stressAutophagyMitochondrial dysfunctionThis study investigated the therapeutic effects of astragaloside IV (AST) on spinocerebellar ataxia type 3 (SCA3), also known as Machado-Joseph disease (MJD), a neurodegenerative disorder. Human neuroblastoma SK-N-...
Ataxin-3 (Atxn3) is a deubiquitinase with a polyglutamine (polyQ) repeat tract whose abnormal expansion causes the neurodegenerative disease, Spinocerebellar Ataxia Type 3 (SCA3; also known as Machado-Joseph Disease). The ubiquitin chain cleavage properties of Atxn3 are enhanced when the enzyme is...
CAG repeat size influences the progression rate of spinocerebellar ataxia type 3. Ann Neurol. 2021;89:66–73. Article CAS PubMed Google Scholar Ning L, Luo W. Specifying turning point in piecewise growth curve models: challenges and solutions. Front Appl Math Stat. 2017; 3. Kohli N, ...
Spinocerebellar ataxia type 3 (SCA3) is a polyglutamine disorder caused by a CAG repeat expansion in the ataxin3 gene resulting (amongst others) in toxic protein aggregation. Inflammation and oxidative stress are secondary factors contributing to the progression of the disease. There is no cure that...
SPINOCEREBELLAR ataxiaQUALITY of lifeNEUROANATOMYMAGNETIC resonance imagingDISEASE progressionObjective: Fatigue is a significant symptom in patients with spinocerebellar ataxia type 3 (SCA3). This study explores the role of fatigue in SCA3, examining its impact on quality of life and its ...
There is no FDA-approved drug for neurological disorders like spinocerebellar ataxia type 3. CAG repeats mutation in the ATXN3 gene, causing spinocerebellar ataxia type 3 disease. Symptoms include sleep cycle disturbance, neurophysiological abnormalities
2) spinocerebellar ataxia type 1 遗传型脊髓小脑共济失调Ⅰ型 3) heredity 遗传 1. Effects ofheredityon prevalence of children obesity and obesity-associated factors; 遗传对儿童肥胖及相关因子分泌影响 2. Research onheredityof gentamicin-induced deafness in guinea-pigs; ...
2) spinocerebellar ataxia type 3 and Machado-Joseph disease(SCA3/MJD) 脊髓小脑型共济失调Ⅲ型/马查多-约瑟夫病3) spinocrebellar ataxia 3/Machado-Joseph disease 脊髓小脑型共济失调III型/马查多-约瑟夫病4) Spinocercbellar ataxia type 3 脊髓小脑共济失调3型 1. Objective: To detect the clinical ...
脊髓小脑共济失调3型 1. Objective: To detect the clinical features of patients of Spinocercbellar ataxia type 3 (SCA3/MJD),we knowed its clinical characteristics detailedly. 目的:通过对新疆脊髓小脑共济失调3型(SCA3/MJD)家系患者的临床表现的调查,了解其临床特点,并对家系成员及患者进行基因分析,进而研...