Gene expression levels for IL-1, tumor necrosis factor α (TNFα), interleukin-10 (IL-10), and transforming growth factor β (TGFβ) decreased, while that for interleukin-4 (IL-4) increased, in hMSC-injected wild-type mice. In contrast, IL-1, TGFβ, and IL-4 gene expression levels...
In this analysis, only baseline ambulatory status, primary tumor type, and extent of metastases were prespecified. Ambulatory response was examined among patients who were alive beyond 48 weeks (long-term survivors) in a post hoc analysis. To evaluate the effect of missing data on the primary ...
For example, naked DNA can be injected directly into skeletal muscle, liver, heart muscle, and tumor tissue. For systemic administration, plasmid DNA may need to be protected from degradation by endonucleases during delivery from the site of administration to the site of gene expression. Bio...
An Emerging Role of Inflammasomes in Spinal Cord Injury and Spinal Cord Tumor. Front. Immunol. 2023, 14, 1119591. [Google Scholar] [CrossRef] Beattie, M.S.; Farooqui, A.A.; Bresnahan, J.C. Review of Current Evidence for Apoptosis after Spinal Cord Injury. J. Neurotrauma 2000, 17, ...
The latter, when present, can generate concern over presence of a spinal cord tumor [123]. Chronic necrosis caused by NMOSD can in some cases result in spinal cord cavitation and cystic myelomalacia. Small areas of strong hyperintensity, higher than that of the surrounding cerebrospinal fluid (...
Tumor necrosis factor alpha protects against lethal West Nile virus infection by promoting trafficking of mononuclear leukocytes into the central nervous system. J. Virol. 2008, 82, 8956–8964. [CrossRef] [PubMed] 32. Brien, J.D.; Daffis, S.; Lazear, H.M.; Cho, H.; Suthar, M.S.;...
Symptoms may include the loss of motor, sensory, and autonomic nervous system functions immediately after the injury, and later problems such as muscular atrophy, chronic pain, and urinary infection, in parts of the body which are present below the lesion level [1,2] of the spinal cord. ...