ARTICLES Inherited Motor Neuron Disease in Domestic Cats: A Model of Spinal Muscular Atrophy QIANCHUAN HE, CHARLES LOWRIE, G. DIANE SHELTON, RUDY J. CASTELLANI, MARILYN MENOTTI-RAYMOND, WILLIAM MURPHY, STEPHEN J. O'BRIEN, WILLIAM F. SWANSON, AND JOHN C. FYFE Laboratory of Comparative Medical ...
In subject area: Neuroscience The anterior horn of the spinal cord is defined as the region primarily affected in spinal muscular atrophy, leading to the loss of motor neurons and subsequent muscle atrophy. AI generated definition based on: Neuromuscular Disorders, 2016 About this pageSet alert Als...
They may occur together with the pain or each may be isolated. They are present at an advanced stage of the disease and they generally accompany a massive narrowing of the spinal canal or the intervertebral openings [28,29]. These symptoms are radicular in nature, but in the case of multi...
In general, the earlier the symptoms appear, the shorter the lifespan. As the motor neuron cells deteriorate, symptoms appear shortly afterward. The severe forms of the disease are fatal and all forms have no known cure. Infants with a severe form of SMA frequently succumb to respiratory ...
All these symptoms regressed in a few days and recovery was almost complete in two to six weeks. Controversy, however, arose as to the occurrence of concussion in the spinal cord of man. Wagner (1896) concluded that the pathological condition in con cussion of the spinal cord was to ...
a variety of neurological symptoms arise due to a dramatic slowing of neurotransmission. Diseases accompanied by such demyelination are generally referred to as demyelinating diseases, and typically include, for example, multiple sclerosis. Spinal cord injuries, too, are generally accompanied by demyelinati...
In conditions of weightlessness, a range of physiological alterations and symptoms (headward fluid shifts; headaches; back pain; and changes in the cardiovascular, bone, and muscle systems) are developed in human and experimental animals [3]. They are collectively referred to as space adaptation ...
ADSCs were shown to have potential beneficial roles in the treatment of several neurological disorders or symptoms. They were shown to confer neurological improvement when used following an ischemic stroke and were demonstrated to aid in neuroinflammation modulation in rat models with sciatic nerve const...
In addition, phosphodiesterase type 5 (PDE5) inhibitors such as tadalafil, which increase cellular levels of cGMP, have been used for the treatment of LUT symptoms in males with benign prostate hypertrophy. Previous studies using SCI rodent models showed that expression levels of neuronal NO ...