157 Topical Seminar Summary: SPINAL INJECTIONS FOR PAIN CONTROL: WHAT IS THE EVIDENCE?doi:10.1016/S1090-3801(06)60160-2S. ErdineJohn Wiley & Sons, LtdEuropean journal of pain (London, England)
Medi- cation placed above the level of pathology will be expected to migrate cephalad, away from the pathology.Although the technique is relatively effective for acute radiculopathy and radiculitis,6 it gives only short- term relief of nonspecific low back pain.7ANDREA TRESCOT...
One-way ANOVA (Dunnett’s multiple-comparisons test); F2,18 = 7.60 (1 mW), F2,16 = 7.49 (6.5 mW); n = 6, 6, 9 mice (0.4 mW), 6, 7, 9 mice (1 mW), 8, 5, 6 mice (6.5 mW) for control, Gpr83, Tacr1, respectively. c, Schematic of lumbar injections of AAV1–hSyn...
Gene-silencing of spinal PKCα reduces the inflammatory pain maintenance. (a) Western blot analysis of the PKCα protein expression level in the dorsal horn of spinal cord in rats after intrathecal injections of AS ODN specific to PKCα, but not MS ODN. Top: Western blot examples for PKCα...
This represents another potential benefit of chondroitin sulfate as an anti-inflammatory pain control. For further information, I am also sharing the following paper on attenuating the MAPK p38 pathway for neuropathy pain relief (Chen et al). Please know I am not expert in such deep subject cell...
Rat BMSCs modified Allen's impact method Immediately after injury 1× 106 cells/mL injected I/V Grade 0: no movement for hindlimbGrade 1:no weight bearing grade 3:rats can move 1–2 stepsgrade 4:rats tolerate slight pain.grade 5: rats walk normally. The treated groups exceeded the untrea...
In general, facet joint injections produce variable results. The back or neck pain may: Not be relieved at all Only provide partial relief Return after a few days, weeks, or months May not recur It is unclear why the results of facet injections vary and who will respond best. ...
The impact of spinal DH injections of NCX3 or control (eGFP-expressing) AAV on pain behavior was then assessed in C57BL/6 mice. NCX3 was effectively expressed by DH neurons (and not by DRG neurons) following intraspinal injection (Figures 8E, 8F, and S8J–S8N). There was no significa...
the first to demonstrate the usefulness of a DL model trained using radiographs in predicting the therapeutic outcomes of spinal injections for radicular pain. Integrating our research results with a cloud system could significantly enhance its accessibility and scalability. A cloud-based platform would ...
Pain decreases the activity of many ventral tegmental area (VTA) dopamine (DA) neurons, yet the underlying neural circuitry connecting nociception and the DA system is not understood. Here we show that a subpopulation of lateral parabrachial (LPB) neurons is critical for relaying nociceptive signals...