There is an open-label, dose-escalation, multicenter clinical trial with C4-7 subacute AIS grade A or B in patients with SCI, who received a single dose of OPC administered by intraparenchymal injection into the spinal cord at the site of injury. At one-year follow-up, 21/22 (96%) of...
From this time onwards Schwann cells were beginning to show cytological evidence of recovery. The paralysis of the hind limbs that occurs 1 day after injection of colchicine by this route is ascribed to disturbances of Schwann cell function. The proposition is also discussed that the axon ...
The role of intracavernous injection of vasoactive medications for the restoration of erection in spinal cord injured males: a three year follow-up. Paraplegia 1992; 30: 118. CAS PubMed Google Scholar Derry F, Hultling C, Seftel AD, Sipski ML . Efficacy and safety of sildenafil citrate (...
UCMSCs group (group A) in which UCMSCs suspension injection was conducted; DMEM control group (group B) in which 10% DMEM injection was conducted; sham group (group C) in which the animal received laminectomy only. Establish acute SCI model (T10) by Impactor model-II device in group A ...
time of injection. Of those, two remained AIS A at the last follow-up, while three changed from AIS A to B (two patients) and to AIS C (one patient) at week 96. Four of the five patients that were classified as AIS B or C at injection demonstrated improvement in AIS grade. The ...
The time from injection to recovery of motor and sensory functions and ambulation time were significantly shorter in the epidural group than the spinal group (p 0.05). The percentage of patients who required additional analgesic was 9% versus 6% in spinal versus epidural groups. One of the ...
Based on its proposed neuroprotective role, we have evaluated the effects of a single, acute intraparenchymal injection of leptin in a clinically relevant animal model of spinal cord injury. As determined by quantitative Real Time-PCR, endogenous leptin and the long isoform of the leptin receptor ...
[43]. Several factors might be able to explain this. First, it is unknown whether eight weeks was sufficient, as axonal regeneration takes considerable time. In previous experiments where IGF-1 and OPN were overexpressed via virus injection into the cortex, it took 12 weeks to observe axonal ...
Eight minutes after injection, the spinal cord was illuminated for 5 min with the full-spectrum light of a halogen bulb (150W, 7 cm distance). To prevent damage by the heating source from the halogen light, the spinal cord was bathed with saline during the illuminating time. Immediately ...
These animals were sacrificed one day after the last injection. Non-inducible FoxJ1-EGFP (Ostrowski et al., 2003) with FoxJ1 promoter driving GFP expression were used for embryo collection at E13.5, E15.5, E17.5, P0, P5 and P10. 2.2. Surgical Procedure and Postoperative Care Mice were ...