2012. Stem cell therapy for the spinal cord. Stem Cell Res Ther 3:24.Donnelly EM, Lamanna J, Boulis NM. Stem cell therapy for the spinal cord. Stem Cell Res Ther. 2012; 3 :24. doi: 10.1186/scrt115. [ Cross Ref ]Donnelly EM, Lamanna J, Boulis NM: Stem cell therapy for the ...
In his Correspondence 'Caution urged in trial of stem cells to treat spinal-cord injury' (Nature 458,29; 2009), Yves Barde questions the wisdom of testing oligodendrocyte precursors derived from embryonic stem (ES) cells in patients, despite the promise that such cells hold for repairing these...
Injury and disease of the spinal cord are generally met with a poor prognosis. This poor prognosis is due not only to the characteristics of the diseases but also to our poor ability to deliver therapeutics to the spinal cord. The spinal cord is extremel
Table 2 Traumatic and motor neuron disease of the spinal cord, and potential for stem cell transplant Full size table Stem cells, or stem cell-derived cells, can most simply be used to replace lost cells such as oligodendrocytes, neurons, motor neurons and astrocytes. These cells may also pro...
Using clonal and subclonal analyses we demonstrate that, in contrast to progenitors isolated from the adult mouse spinal cord with a combination of growth factors, progenitors isolated from the adult rat spinal cord using basic fibroblast growth factor alone display stem cell properties as defined by...
Researchers at University of California San Diego School of Medicine report that they have successfully created spinal cord neural stem cells (NSCs) from human pluripotent stem cells (hPSCs) that differentiate into a diverse population of cells capable o
Stem cells have proven beneficial in rodent models of spinal cord disease and injury. In these animal models, stem cells have been shown to produce their effect by the dual action of cell replacement and the trophic support of the factors secreted by these cells. In this review we look at ...
2) spinal cord-derived neural stem cell 脊髓来源神经干细胞 3) Embryonic spinal cord neurons 脊髓神经细胞 1. Effect of basic fibroblast growth factor on activity of the embryonic spinal cord neurons in culture; 碱性成纤维细胞生长因子对培养大鼠胚胎脊髓神经细胞的作用 ...
3. Stem/Progenitor Cell Therapy for Spinal Cord Injury Human embryonic stem cells (hESCs) are pluripotent cells, derived from the inner cell mass of the early blastocyst, that can be propagated in vitro for a long period and represent a theoretically inexhaustible source of precursor cells that ...
Stem cell therapy has the potential to provide a valuable treatment approach for spinal cord injury, but no consensus yet exists regarding which type of stem cell is likely to be most effective in the clinical setting. In this article, Sahni and Kessler