Spina bifida aperta (SBA) can cause severe lifelong physical and neurodevelopmental disabilities. Experimental and clinical studies have shown that the neurological deficits associated with SBA are caused by a combination of incomplete neurulation (first hit) and additional damage caused by prolonged ...
Myelomeningocele is the most severe form of spina bifida. A portion of the spinal cord or nerves is exposed in a sac through an opening in the spine that may or may not be covered by the meninges.The opening can be closed by surgeons while the baby is in utero or shortly after the ...
They may also have paralysis below the level of the opening in their spine. Infant Spina Bifida Diagnosis and Treatment Spina bifida is often diagnosed in utero. Abnormalities on an ultrasound can lead to a diagnosis. When this happens, intrauterine surgery may allow for a better long-term outc...
Stem Cell-Based Strategies for Prenatal Treatment of Spina Bifida and the Promise of Cell-Free, Minimally Invasive Approaches 来自 Springer 喜欢 0 阅读量: 1 作者:B Corradetti,F Taraballi,RH Finnell 摘要: Spina bifida (SB) is a severe birth defect that affects 1400 newborns annually in the ...
Similar to Duchenne muscular dystrophy patients, the loss of muscle function in patients with spina bifida can also be accompanied by fatty infiltration. The current standard for clinical measurement of lower extremity muscle function is manual muscle testing (MMT) 1,2 , which provides only a semi...
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Spina bifida aperta is a type of neural tube defect (NTD). Although prenatal fetal surgery has been an available and effective treatment for it, the neurological functional recovery is still need to be enhanced. Our previous results revealed that deficiencies of sensory, motor, and parasympathetic...
Table 2. Mean (standard deviations) for raw and corrected (raw to total brain volume) deep gray matter structures for participants with spina bifida myelomeningocele (SBM; n = 48) and typically developing controls (TD; n = 18). Values reflect averages between left and right hemispheres. Emp...
A team of specialists at UPMC Magee-Womens Hospital and UPMC Children's Hospital of Pittsburgh have performed UPMC's first in-utero surgery to close an open neural tube defect in a baby months before her birth. Ad When Allee Mullen was pregnant, her baby was diagnosed withspina bifida, abi...
In the meantime, the team wants dog breeders to send more puppies with spina bifida to UC Davis for treatment and refinements that help the researchers fix an additional hallmark of spina bifida—incontinence. While Darla and Spanky are very mobile and doing well on their feet, they still requ...