Spin freeze‐drying process is a recently proposed method to achieve continuous processing of unit doses in freeze‐drying application. An experimental study is carried out to investigate the heat transfer and drying characteristics of a spin‐frozen liquid product. To enhance heat transfer, unlike ...
An experimental study on formation of ice patterns during spin freezing of liquid in vials and the effect of such ice patterns in the freeze-drying process is investigated. The process is carried out in vials for liquids such as distilled water and skimmed milk which are immersed and spun in...
More specifically, the present invention relates to freeze-dry nucleic acid containing compositions using a method of continuous spin freezing and continuous spin drying (sublimation and desorption) the composition. The invention further relates to a nucleic acid containing composition by making use of ...
Evaluation of immersion‐contact type heat transfer for continuous pharmaceutical spin freeze‐drying processdoi:10.1111/jfpe.13153Ganeshmurthy SrinivasanBalakrishnan RajaJohn Wiley & Sons, Ltd (10.1111)
Spin-freezing as alternative freezing approach was evaluated as part of an innovative continuous pharmaceutical freeze-drying concept for unit doses. The aim of this paper was to compare the sublimation rate of spin-frozen vials versus traditionally frozen vials in a batch freeze-dryer, and its ...
Freeze-dryingCooling curveDrying rateHeat transfer coefficientHEAT-TRANSFERRIMMING FLOWQUALITYSTEPPHARMACEUTICALSJournal of Thermal Analysis and Calorimetry - An experimental study was carried out to analyze the cooling curve and drying behavior of static and spin-frozen samples (distilled water and skimmed....
Disclosed are a method for fabricating a bioactive membrane by combining spin coating technology and freeze-drying technology, and a bioactive membrane fabricated by the method. The method to fabricate the bioactive membrane, according to an embodiment of the present invention, comprises the following ...
Disclosed are a method for manufacturing a bioactive membrane by fusion of spin coating technique and freeze-drying technique and a bioactive membrane produced thereby. The method for manufacturing the bioactive membrane according to an embodiment of the present invention comprises the following steps: ...
Disclosed are a method for preparing a bioactive membrane by combining a spin coating technique and a freeze-drying technique, and a bioactive membrane prepared thereby. The method for preparing a bioactive membrane, according to one embodiment of the present invention, comprises the steps of: (a1...
Disclosed are a method for manufacturing a bioactive membrane by fusion of spin coating technique and freeze-drying technique and a bioactive membrane produced thereby. The method for manufacturing the bioactive membrane according to an embodiment of the present invention comprises the following steps: ...