“We started giving Dravet syndrome mice the spider-venom peptide after they developed serious seizures, and within four days we had eliminated all the seizures and the mice were saved from premature death,” King says. “That is really exciting, but the issue now is how to best deliver that...
Spider venomSpider toxinsCancerAnticancerDrug discoveryNatural productsCancer is a generic term for a large group of diseases characterized by an abnormal growth of cells that evade from programmed cell death (apoptosis), invade tissues, spread in the body (metastasis). It is responsible for the ...
Some toxins have been isolated and purified, such as a phospholipase-D, from the venom of brown spider that displays high hemolytic activity in red blood cells (Silva et al., 2004), which could present anti-cancer action. Also, hyaluronidases found in the venom of some spiders could be ...
No anti-cancer spider-derived drug has yet been clinically applied, likely because research intospider venom peptidesaffecting cancer is still relatively in its infancy. Several of the anti-cancer spider venom peptides that have been discovered also exhibit potent off-target toxicity. However, as ...
The activity of caspase-3 was upregulated after spider venom treatment. In vivo study of tumor size revealed that tumors significantly decreased in size from controls to tumors treated for 3 weeks with spider venom (P<0.05). Conclusion: The inhibition of HeLa cells by the venom of the spider...
The venom of the poisonous banana spider has led to the discovery of a molecule which will treat erectile dysfunction. Three decades ago, Brazilian researchers began studying a curious side effect from banana spider bites: the toxin left victims with priapism, a painful and persistent erection. ...
This combination of pharmaceutical properties has made venom toxins valuable both as pharmacological tools and as leads for drug development. These highly tunable molecules can be tailored to achieve desirable biocompatibility and biodegradability with simultaneously selective and potent therapeutic effects. ...
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Treatment. Most human patients envenomated by the brownrecluse spiderdo not require treatment.1Treatment of brown recluse envenomation is controversial in the humanliterature because there is a lack of well-controlled clinical studies of treatment efficacy. Animals with suspected brown recluse bites shou...
venom peptides valuable pharmacological tools used to elucidate the structure and physiological roles of the channels in excitable and non-excitable cells gaining importance in neurobiology. Additionally,spider toxinshave become leads for drug development in pain, stroke and cancer (King, 2011; Mazzuca ...