K145盐酸盐是SphK2选择性抑制剂,IC50为4.3μM,在10μM浓度时对SphK1无抑制性。注:本品仅可用于科研实验,严禁用于临床医疗及其他用途!CAS号:1449240-68-9别名:SphK2 inhibitor纯度:98.00%分子式:C18H25ClN2O3S分子量:384.92结构式:储存条件:-20℃,有效期2年,溶入溶剂后-20℃请尽量在一个月内使用。相关...
中文名称:SphK2抑制剂(K145盐酸盐)英文名称:K145 hydrochloride 产品规格:1mL(10mM)|5mg|10mg|50mg|100mg 发货周期:1～3天 K145盐酸盐是SphK2选择性抑制剂,IC50为4.3μM,在10μM浓度时对SphK1无抑制性。 注:本品仅可用于科研实验,严禁用于临床医疗及其他用途! CAS号:1449240-68-9 别名:SphK2 inhibitor ...
K145盐酸盐是SphK2选择性抑制剂,IC50为4.3μM,在10μM浓度时对SphK1无抑制性。 注:本品仅可用于科研实验,严禁用于临床医疗及其他用途! CAS号:1449240-68-9 别名:SphK2 inhibitor 纯度:98.00% 分子式:C₁₈H₂₅ClN₂O₃S 分子量:384.92 ...
别名:SphK2 inhibitor 特别提示:包括SphK2抑制剂(K145盐酸盐)在内,本公司的所有产品仅可用于科研实验,严禁用于临床医疗及其他非科研用途!产品名称:SphK2抑制剂(K145盐酸盐)英文名称:K145 hydrochloride产品货号:M00768产品规格:1mL(10mM)|5mg|10mg|50mg|100mgK145盐酸盐是SphK2选择性抑制剂,IC50为4.3μM,在10...
K145盐酸盐是SphK2选择性抑制剂,IC50为4.3μM,在10μM浓度时对SphK1无抑制性。 注:本品仅可用于科研实验,严禁用于临床医疗及其他用途! CAS号:1449240-68-9 别名:SphK2 inhibitor 纯度:98.00% 分子量:384.92 储存条件:-20℃,有效期2年,溶入溶剂后-20℃请尽量在一个月内使用。
SG12 and SG14 mutually showed stronger inhibitory effects with less cytotoxicity compared with a general SphK inhibitor, N,N-dimethylsphingosine (DMS). The mechanistic aspects of specific SphK2 inhibition were studied by examining actin filamentation as well as the expression levels of motility-...
The SphK activity was remarkably inhibited by ABC294640, accompanied by sphingosine-1-phosphate (S1P) depletion and ceramide incensement in CRC cells. Exogenously-added S1P inhibited ABC294640-induced HT-29 cell lethality. While C6 ceramide and SphK1 inhibitor SKI-II facilitated ABC294640-induced ...
Opaganib (ABC294640) is a specific SPHK2 inhibitor that prevents sphingosine from being phosphorylated into its active form by competitively binding SPHK2, thereby effectively reducing intracellular S1P levels and confining inflammatory signaling pathways [38]. Opaganib has been shown to reduce mortality ...
SPHK2 associates with HDAC1 and HDAC2 in repressor complexes and is selectively enriched at the promoters of the genes encoding the cyclin-dependent kinase inhibitor p21 or the transcriptional regulator c-fos, where it enhanced local histone H3 acetylation and transcription. SphK2 is most abundantly...
SPHK2 associates with HDAC1 and HDAC2 in repressor complexes and is selectively enriched at the promoters of the genes encoding the cyclin-dependent kinase inhibitor p21 or the transcriptional regulator c-fos, where it enhanced local histone H3 acetylation and transcription. SphK2 is most abundantly...