SPHK2 associates with HDAC1 and HDAC2 in repressor complexes and is selectively enriched at the promoters of the genes encoding the cyclin-dependent kinase inhibitor p21 or the transcriptional regulator c-fos, where it enhanced local histone H3 acetylation and transcription. SphK2 is most abundantly...
此外,通过shRNA敲除或抑制SPHK2可显著降低LPS诱导的M1巨噬细胞极化、氧化应激和NLRP3炎性小体激活。进一步研究表明,上调SPHK2可提高核1-磷酸鞘氨醇(S1P)水平,进而抑制HDACs酶活性,促进p53乙酰化。p53的乙酰化增强了其与NLRP3启动子特定区域的结合,并驱动NLRP3的表达。 在体内实验中,观察到SPHK2特异性抑制剂Opagan...
SPHK2 associates with HDAC1 and HDAC2 in repressor complexes and is selectively enriched at the promoters of the genes encoding the cyclin-dependent kinase inhibitor p21 or the transcriptional regulator c-fos, where it enhanced local histone H3 acetylation and transcription.SphK2 is a ~66kDa ...
S3D). These data demonstrated that nuclear S1P promoted p53 acetylation via inhibiting the enzymatic activity of HDACs in LPS-treated macrophages. Fig. 4: The activation of nuclear SPHK2/S1P signaling promotes p53 acetylation in LPS-induced macrophages. A Gene set enrichment analysis (GSEA) ...
SPHK2 associates with HDAC1 and HDAC2 in repressor complexes and is selectively enriched at the promoters of the genes encoding the cyclin-dependent kinase inhibitor p21 or the transcriptional regulator c-fos, where it enhanced local histone H3 acetylation and transcription. SphK2 is most abundantly...
SPHK2 associates with HDAC1 and HDAC2 in repressor complexes and is selectively enriched at the promoters of the genes encoding the cyclin-dependent kinase inhibitor p21 or the transcriptional regulator c-fos, where it enhanced local histone H3 acetylation and transcription.SphK2 is a ~66kDa ...
Further study indicated that upregulated SPHK2 could increase nuclear sphingosine-1-phosphate (S1P) levels and then restrict the enzyme activity of HDACs to facilitate p53 acetylation. Acetylation of p53 reinforced its binding to the specific region of the NLRP3 promoter and drove expression of ...
Further, PA infection of the epithelial cells enhanced NOX4 dependent nuclear reactive oxygen species (ROS) production and oxidation of histone deacetylase (HDAC) 1 & 2, which was dependent on PKC δ and SphK2 activation and was blocked by N-acetylcysteine. The clinical significance of our ...
Aberrant sphingolipid metabolism has been implicated in chemoresistance, but the underlying mechanisms are still poorly understood. Herein we revealed a previously unrecognized mechanism of 5-fluorouracil (5-FU) resistance contributed by high SphK2-upreg
HDAC6抑制剂(Tubastatin A盐酸盐) 价格: ￥3800/瓶 产品详情: 特别提示:包括HDAC6抑制剂(Tubastatin A盐酸盐)在内,本公司的所有产品仅可用于科研实验,严禁用于临床医疗及其他非科研用途... SphK2抑制剂(K145盐酸盐)相关供应商报价 更多> 产品标题 价格 产地 公司名称 更新日期 K145 hydrochloride 电议 VIP...