The sphingosine 1-phosphate signaling pathway in epilepsy:A possible role for the immunomodulator drug fingolimod in epilepsy treatment. Leo A,Citraro R,Marra R,et al. CNS Neurol Disord Drug Targets . 2017The Sphingosine 1-Phosphate Signaling Pathway in Epilepsy:A Possible Role for the ...
S1P serves as a ligand for a family of five G‐protein‐coupled receptors with distinct signaling pathways regulating important biological pathways. S1P induces renal fibrosis through an inflammatory pathway. However, its direct fibrosis‐inducing effect on the kidney has not been shown. The role of...
Sphingosine-1-Phosphate Protects Intestinal Epithelial Cells from Apoptosis Through the Akt Signaling Pathway Digestive Diseases & SciencesSphingosine-1-Phosphate Protects Intestinal Epithelial Cells from Apoptosis Through the Akt Signaling Pathway[J] . Jose Greenspon,... J Greenspon,R Li,L Xiao,... -...
Remarkably, both S1PP and S1PL are located on the ER, which ensures that unwanted S1P can be locally metabolized to stop SK1-mediated autophagic signaling. Finally, we demonstrate the importance of the S1P pathway in the autophagic degradation of an autophagy substrate, the mHtt fragment Httex...
The sphingosine kinase/SPP signaling pathway is also crit- ically involved in mediating TNF-K-induced endothelial cell activation [10]. Furthermore, the ability of high density lipo- proteins (HDL) to inhibit cytokine-induced adhesion molecule ...
The mTOR signaling pathway is a central regulator of autophagy. It has a multifaceted impact on the initiation and subsequent stages of the autophagy process, as has been extensively documented [39,40]. By directly phosphorylating and suppressing the ULK1 complex, which is crucial for the initiatio...
The sphingosine kinase/SPP signaling pathway is also critically involved in mediating TNF-K-induced endothelial cell activation [10]. Furthermore, the ability of high density lipoproteins (HDL) to inhibit cytokine-induced adhesion molecule expression correlates with its ability to reset the sphingolipid...
(Hla et al. 2008). This gradient provides a cue for lymphocyte trafficking, and S1PR1 signaling plays a major role in modulating lymphocytes’ access to inflammation sites. Therefore, the S1P-S1PR1 pathway is of interest to researchers developing drugs for multiple sclerosis (MS), inflammatory ...
The mTOR signaling pathway is a central regulator of autophagy. It has a multifaceted impact on the initiation and subsequent stages of the autophagy process, as has been extensively documented [39,40]. By directly phosphorylating and suppressing the ULK1 complex, which is crucial for the initiatio...
sphingosine-1-phosphate signaling pathwayimmune responseG-protein coupled receptor signaling pathwayadenylate cyclase-activating G-protein coupled receptor signaling pathwayactivation of phospholipase C activitypositive regulation of cytosolic calcium ion concentration...