Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ - Jr, Echten, et al. () Citation Context ...ces a mycoprotein called fumonisin B1, which has structural similarities to sphinganine and sphingosine. Consequently, it ...
Fumonisin B1 selectively inhibits sphinganine N-acyltransferase and rapidly accumulates sphin- ganine quite early. Among sphingosine kinase inhibi- tors tested, FTY720 preferentially increased the sphin- gosine level rather than sphinganine. Unlike the other inhibitors, the specific increase in sphingosine ...