Sphingosine-1-phosphateEDG-1Sphingosine kinaseCell growthApoptosisThe sphingolipid metabolite sphingosine-1-phosphate (S1P) is a serum-borne lipid that regulates many vital cellular processes. S1P is the ligand of a family of five specific G protein-coupled receptors that are differentially expressed in...
The bioactive lipid sphingosine 1-phosphate (S1P) is a degradation product of sphingolipids that are particularly abundant in neurons. We have shown previously that neuronal S1P accumulation is toxic leading to ER-stress and an increase in intracellular calcium. To clarify the neuronal function of ...
S1P, also referred to as sphingosine-1-phosphate, is a lipid molecule with bioactive properties involved in numerous cellular processes such as cell growth, movement, programmed cell death, self-degradation, cell specialization, aging, and immune system reactions. Autophagy is a meticulously controlled...
Sphingosine-1-phosphate (S1P), a bioactive lipid molecule localized in the blood plasma, has been implicated in regulating endothelial barrier function1, and the biological effect of S1P has been shown to be flow-dependent. For example, application of laminar shear stress (LSS) upregulates the ...
A growing body of evidence suggests that sphingosine kinase 1 (SK1)/ sphingosine 1-phosphate (S1P) pathway contributes to vascular dysfunction through dysregulation of Ca 2+ mobilization. We demonstrated recently that intracellular S1P triggers store-operated Ca 2+ (SOC) entry and independent of G...
Cutting edge: CD69 interference with sphingosine-1-phosphate receptor function regulates peripheral T cell retention. Cutting edge: CD69 interference with sphingosine-1-phosphate receptor function regulates peripheral T cell retention. J. Immunol. 194:2059-2063. http:/... K Laura,Mackay,Asolina...
Sphingosine-1-phosphate详情 评价(0) 货号:ajci18250 CAS:26993-30-6 别名:D-苏式-鞘胺醇-1-磷酸,Sphingosine-1-phosphate (d18:1); S1P (d18:1); Sphingosine-1-Phosphoric Acid 分子式:C18H38NO5P 分子量:379.5 纯度:>98% 溶解度:≤4 mg/ml in 0.3M NaOH,<50 μg/ml in DMF,<50 μg/ml...
1. Synthesis and metabolism of sphingolipids 2. The sphingosine kinase family 3. Sphingosine kinases and production of sphingosine-1-phosphate 4. Mechanisms of sphingosine kinase activation 5. Sphingosine kinases, S1P and apoptosis 6. S1P regulates ceramide biosynthesis and apoptosis 7. Sphingosine kina...
1.Introduction Sphingosine-1-phosphate(SPP)isabioactivesphingolipid metabolitewhoseimportanceincellgrowthregulationwas discoveredinourlabin1991[1].Overtheensuingdecade, wehavebeenconstantlyintriguedbythewidespectrumof biologicalprocesses,includingcalciummobilization,cell ...
The sphingolipid metabolite, sphingosine-1-phosphate (S1P), has emerged as a critical player in a number of fundamental biological processes and is important in cancer, angiogenesis, wound healing, cardiovascular function, atherosclerosis, immunity and asthma, among others. Activation of sphingosine kinas...