RNA-seq analysis revealed that the sphingolipid metabolism pathway is likely a key player in ROD pathogenesis, thereby providing new avenues for therapeutic intervention.Yujia WangInstitute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, Jiangsu 210003, ChinaYan Di...
47 sphingolipid genes (KEGG ID: hsa00600, sphingolipid metabolism) were obtained from the KEGG database. After the intersection of sphingolipid genes with TCGA-LIHC (47 genes), 20 genes were screened by univariate analysis (Fig. 1A, p < 0.05). The NMF clustering method was further utilized ...
6A). In addition, sphingolipid metabolism and sphingolipid signaling pathways also appeared in the KEGG enrichment analysis (Fig. 6B). Notably, similar to transcriptomics, the HIF-1 signaling pathway and FoxO signaling pathway were also included in the KEGG enrichment results of DEPs (Fig. 6B). ...
Imbalances in sphingolipid metabolism could drive the dysbiotic state observed prior to onset, either by directly affecting the bacteria or through their signaling function in the immune response. Another potential limitation is that we focused on stool. While it seems logical to seek biomarkers in ...
Fig. 1. Alteration of sphingolipid metabolic gene expression that involved in the metabolism of bioactive sphingolipids strongly correlates with poor prognosis in NSCLC patients. (a) Metabolic network shows selected sphingolipid metabolic reactions (Kyoto Encyclopedia of Genes and Genomes pathway, KEGG),...
47 sphingolipid metabolism genes were obtained from the Kyoto Encyclopedia of Genes and Genomes (KEGG) database. After classifying HCC samples using the Non-negative Matrix Factorization (NMF) clustering method, differentially expressed genes were screened. Then, 8 risk genes were obtained by ...
RNA-seq analysis revealed that the sphingolipid metabolism pathway is likely a key player in ROD pathogenesis, thereby providing new avenues for therapeutic intervention.Yujia WangInstitute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, Jiangsu 210003, China;Institute ...
Among the GALC downregulated proteins, we identified a cluster of 42 proteins significantly associated with GO and KEGG categorizations related to mitochondrion and energetic metabolism. Overall, our data indicate that changes in GALC expression may exert a significant impact on mitochondria...
GO, KEGG and GSEA pathway analyses indicated that these genes were highly enriched in functions related to lipid metabolism pathway, sphingolipid signaling pathway, among others. The differential expression of alkaline ceramidase 1(Acer1), ceramide synthase 4 (Cers4) sphingomyelin phosphodiesterase 3...
“nicotinate and nicotinamide metabolism” KEGG. At variance, despite their limited number, the 14 downregulated proteins were found to belong to enriched KEGG pathways and GO terms related to mitochondrial processes, including oxidative phosphorylation, mitochondrial respiratory chain complexes, and aerobic...