SPF-5506-A4, a new peptaibol inhibitor of amyloid beta-peptide formation produced by Trichoderma sp. Hosotani Nobuo,Kumagai Kazuo,Honda Shigeyuki,Ito Akira,Shimatani Takuro,Saji Ikutaro. Journal of Antibiotics . 2007Hosotani, N . , Kumagai, K., Honda, S,, Ito, A., Shimatani, T , Saji,...
(2007). SPF-5506-A4, a new peptaibol inhibitor of amyloid beta- peptide formation produced by Trichoderma sp. J. AntibioLSPF-5506-A4, a new peptaibol inhibitor of amyloid beta-peptide formation produced by Trichoderma sp. Hosotani Nobuo,Kumagai Kazuo,Honda Shigeyuki,Ito Akira,Shimatani Takuro,...
A4.Solution NMR reveals 尾-bend ribbon spiral core structure with flexible termini.SPF-5506-A4 shows low hemolytic activity and preferentially binds anionic membranes.The peptaibol forms large (>4.6nm) non-lytic pores in the membrane.SPF-5506-A4 follows the toroidal pore model in its mode of ...
A new peptaibol compound,SPF-5506-A4,was isolated from the fermentation broth of Trichoderma sp.SPF-5506.The chemical structure of the 14-residue peptide was determined by MS,NMR and amino acid sequence analyses.The absolute configuration of amino acid residues in the acid hydrolysate was ...