SPF-5506-A4, a new peptaibol inhibitor of amyloid beta-peptide formation produced by Trichoderma sp. Hosotani Nobuo,Kumagai Kazuo,Honda Shigeyuki,Ito Akira,Shimatani Takuro,Saji Ikutaro. Journal of Antibiotics . 2007Hosotani, N . , Kumagai, K., Honda, S,, Ito, A., Shimatani, T , Saji,...
SPF-5506. The chemical structure of the 14-residue peptide was determined by MS, NMR and amino acid sequence analyses. The absolute configuration of amino acid residues in the acid hydrolysate was determined by Marfey's method. The structure of SPF-5506-A4 was established as Ac-Aib-L-Asn-L...
A new peptaibol compound,SPF-5506-A4,was isolated from the fermentation broth of Trichoderma sp.SPF-5506.The chemical structure of the 14-residue peptide was determined by MS,NMR and amino acid sequence analyses.The absolute configuration of amino acid residues in the acid hydrolysate was ...