Sodium voltage-gated channel alpha subunit 2; SCZ: Schizophrenia; SHANK2/3: SH3 and multiple ankyrin repeat domains 2/3; SHH: Sonic hedge- hog signaling molecule; SLIT1: Slit guidance ligand 1; SMAD: Small mothers against decapentaplegic; SNAP91: Synaptosome-associated protein 91; SNP: Single...
loss of UBE3A leads to an increased activity of BK channels, which in turn causes neuronal hyperexcitability along with network synchronization. Indeed, antagonists for the affected BK channel could
173. Wu JY, Kuban KC, Allred E, Shapiro F, Darras BT. Association of Duchenne muscular dystrophy with autism spectrum disorder. J Child Neurol 2005;20:790 –795. 174. Buxbaum JD, Cai G, Nygren G, et al. Mutation analysis of the NSD1 gene in patients with autism spectrum disorders ...
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see these resources: Spectrum Accelerate documentation is available in the IBM Knowledge Center at: https://www.ibm.com/support/knowledgecenter/STZSWD_11.5.0/xiv_sds_kc_welcome.ht ml IBM Spectrum Accelerate: Deployment, Usage, and Maintenance, SG24-8267: http://www.redbooks.ibm.com/abstracts/...
an Mg2+binding site binds Mg2+in the presence of hyperpolarized membrane potentials and eventually blocks the opening of the NMDA receptor channel, thus restricting the entry of Ca2+ions. However, when the synaptic membrane is depolarized, Mg2+is removed, thereby allowing access to Ca2+ions. The...
“Let’s Get Together,” Scott McKenzie’s “San Francisco,” The Byrds’ “Turn Turn Turn,” KC & The Sunshine Band’s “Get Down Tonight,” Lynyrd Skynyrd’s “Free Bird” and “Sweet Home Alabama,” Jackson Browne’s “Running on Empty” and Bob Seger’s “Against the Wind,” ...
(SNPs), which overlap genes in common molecular pathways, such as calcium channel signaling, are shared in ASD, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia [14]. CNVs, especially the rare ones, can explain a portion of the risk for ...
Hashimoto RI, Backer KC, Tassone F, Hagerman RJ, Rivera SM . An fMRI study of the prefrontal activity during the performance of a working memory task in premutation carriers of the fragile X mental retardation 1 gene with and without fragile X-associated tremor/ataxia syndrome (FXTAS). J ...
[11], Succinate Dehydrogenase Complex Flavoprotein Subunit A (SDHA), Kinesin Family Member 1A (KIF1A) [12], γ-Aminobutyric Acid Type A Receptor Subunit Beta2 (GABRB2) [13], potassium voltage-gated channel subfamily B member 1 (KCNB1) [2] and Jumonji Domain Containing 1C (JMJD1C) [14...