The installation and on-site training of Department of Health users was to be completed by the first of October, when department IT staff expected to roll out a new version of their Oracle-based inter- nal application software. "One advantage of the 1MAGE product is its transparent ...
The definition of EDC is a non-trivial process, since it entails complex mechanisms that have to be considered and has vast impacts on regulatory aspects and therefore public health. The relevance for a high number of stakeholders is also shown by the recent effort of the Cheroni et al. ...
and rare CNVs, we compiled a variant catalog using 1,251 samples from the International HapMap project. An event is classified as previously observed if there is more than 50% overlap with an event appearing one or more times in the HapMap controls. The pipeline automatically classifies new ...
Studies of individuals with autism spectrum disorder (ASD) have revealed a strong multigenic basis with the identification of hundreds of ASD susceptibility genes. ASD is characterized by social deficits and a range of other phenotypes, implicating compl
through The Center for Autism and Neurodevelopmental Disorders, an entrepreneurial public-private partnership, and National Institutes of Health grant GM048071 (I.P.). Author Contributions G.S., J.J.G., I.P. designed the experiments. G.S., R.L.N., K.K. conducted the experiments; G.S...
In addition, we show that flies mutant for Dmtn, a gene implicated in the health of the central nervous system, are sensitive to ethanol during development. Finally, we show that at least two slow-aging mutants are sensitive to ethanol during development, raising the possibility that ethanol ...
that were performed in cohorts containing individuals of mostly European ancestry (Supplementary Table2). Only SNPs associated with ASD with ap < 5 × 10–8were included in downstream analyses. Phenotypes were defined as the mapped traits associated with the SNP in the GWAS Catalog. ...
(IgG1 isotype control, Invitrogen, Catalog Number MA5–14453) overnight at 4 degrees. An additional anti-peptidoglycan monoclonal Ab (mAb 2E9) was kindly provided by Dr. Chris Power, University of Alberta. 2E9 is an IgG3 mAb originally developed in 1994 as a reagent for the detection of...
Intracellular and surface ACKR3 levels were analyzed by flow cytometry using ACKR3-specific mAb (12.5 µg per ml (dilution 1:40), clone 11G8 (R&D Systems, catalog #MAB42273) or a matched isotype control (12.5 µl per ml, (dilution 1:40) clone MG1-45, BioLegend, #401402...
(e.g., Jindal2015; Jung et al.2017; Milkman et al.2009). While much of that research has taken a consumer psychology perspective and has been tested in lab experiments, quantitative researchers have made major strides in including bounded rational behavior in their models (e.g., Stüttgen ...