The absence of an association between neighbourhood deprivation and self-harm is at odds with much previous research [45,46,47], however is consistent with recent findings that some deprived inner-city areas had paradoxically low rates of self-harm [48] possibly explained by complex social and ...
The genetic etiology of autism spectrum disorder (ASD) is multifactorial, but how combinations of genetic factors determine risk is unclear. In a large family sample, we show that genetic loads of rare and polygenic risk are inversely correlated in cases
Gross and adjusted Odds Ratios (ORa) were used to estimate the magnitude of the associations. Results: Autistic disorder was associated with the presence of meconium in amniotic fluid (AF) (ORa 1.67; 95% confidence interval [95%CI] 1.06–2.65) and ...
A number of different brain disorders have been already modeled and manipulated by taking advantage of brain organoids, such as microcephaly related to CDK5RAP2 mutations [148], or considering an environmental insult, neurodevelopmental delays related to Zika virus exposure [157,158]. Focusing on AS...
Cortese et al16 substantiated this association in a recent meta-analysis of case-control, cohort, and survival studies (odds ratio, 2.57; 95% CI, 1.65-4.03). However, statistical significance was diminished after adjusting for study-level confounders. We selectively included prospective and ...
In case of discrepancies, they discussed with the third researcher until a consensus was reached. Statistical analysis Statistical data analysis was conducted using Review Manager 5.2 and Stata 14.0. For categorical data, odds ratios (OR) were used, and for continuous data, standardized mean ...
In the whole sample, there were 63 cases (1.51%) and 229 controls (1.38%) born after IVF.No significant association was found between IVF and ASDs (adjusted odds ratio (OR): 0.9, 95% confidence interval (CI): 0.7-1.3) or its subtypes childhood autism (OR: 0.8, 95% CI: 0.4-1.5),...
(Fig.1c). In addition to the demonstration of recessive inheritance using genome-wide methods, the evidence includes strong logarithm of odds (LOD) scores in large family pedigrees (ALPK3,FBXO32,KLHL24,LEMD2,PLEKHM2), the enrichment of rare biallelic variants in case versus control cohorts (...
RETROSPECTIVE: SPECTRUM MAGAZINE CELEBRATES 20 YEARS OF PUBLISHING, ODDS-ON FAVORITES FOR THE COMING YEAR: GUESSING HOW THE DICE WILL FALL, WEB SERVICES AND .NET, PART 3: MULTIVALUE TOOLS, UNIVERSE AND UNIDATA HASHED FILES - PART 1, GENERIC SMARTPHONES USER INTERFACE DESIGN, REVELATION TECH TIP...
eTable 1. Diagnosis codes for acute respiratory tract infections eTable 2. Appropriate antibiotics with classification for treatment of acute respiratory tract infections eTable 3. Assessment of balance after full matching for clinical outcomes (n=30086) eTable 4. Odds ratios for clinical outcomes e...