Zaks A,Klibanov A M.Substrate specificity of enzymes in organic solvents vs water is reversed.Journal of American Chemistry Society. 1986Zaks, et al., " Substrate specificity of enzymes in organic solvents vs. water is reversed, " JACS 108: 2767-2768: (1986)....
(AD) is often delayed due to lack ofa simple and effective screening test in primary care settings.To determine sensitivity and specificity of the validated 7 Minute Screen (7 MS) Thai version in screening elders with mild to moderate AD.The original 7 MS was translated and modified to be ...
ALTHOUGH proteolytic activity has been shown by Berridge 1 in a partially crystalline preparation of rennin and by De Baun, Connors and Sullivan 2 in a preparation 75 per cent pure, there has hitherto been no published proof that the activity is not due to contamination. Moreover, it has be...
Aminoacyl-tRNA synthetases are modular enzymes composed of a central active site domain to which additional functional domains were appended in the course ... JC Salazar,A Ambrogelly,PF Crain,... - 《Proceedings of the National Academy of Sciences》 被引量: 142发表: 2004年 An Isolated Class ...
- 《Journal of Biochemistry》 被引量: 84发表: 1991年 Display of active subtilisin 309 on phage: analysis of parameters influencing the selection of subtilisin variants with changed substrate specificity from ... Many attempts have been made to endow enzymes with new catalytic activities. One ...
A picture is emerging in which a selected group of DUSP enzymes display overexpression or hyperactivity that is associated with human disease, especially human cancer, making feasible targeted therapy approaches based on their inhibition. A panoply of molecular and functional studies on DUSPs have ...
This shift is due to a transcriptional change in the expression of the two corresponding isogenes and may account for the improved efficiency of contraction. A similar shift occurs in atria of every animal species, including man, and has also been reported for other isoenzymes such as lactate ...
The success of antibody therapeutics is due in large part to their highly attractive molecular properties, including their high affinities, long half-lives, potent effector functions, and excellent biophysical properties (e.g., high stability and solubility)4,5,6. However, it is well known that ...
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We then applied the method to comprehensively characterize the blood cascade serine proteases. The group of enzymes tested consists of blood coagulation proteases aFVII, aFIX, aFX, aFXI, activated α-Thrombin, PLG and aPC as well as β- and γ-Thrombin. We chose these proteases because they ...