A simple example concerning qualitative analysis can clarify the meaning of and the difference between the terms. At present, there seems to be no uniformity in the analytical literature when describing selectivity, specificity, interferences, and matrix effects....
The difference in efficiency of peptide chain hydrolysis after Lys/Arg residues by enteropeptidase compared to trypsin is equal to the difference in hydrolysis by serine proteases of different primary specificity of their specific substrates. 展开 关键词: Enteropeptidase, trypsin, trypsinogen, ...
The identity of the bases used in the hairpin stem as well as the overall loop length significantly affected sensitivity and selectivity. Surface-immobilized hairpins discriminated between two sequences with a single base-pair mismatch with high sensitivity (over an order of magnitude difference in ...
We confirm the N terminal selectivity and specificity using mass spectral analyses and show near complete retention of the biological activity of our model protein both in vitro and in vivo murine models. We believe that this methodology would be applicable to a variety of potentially therapeutic ...
In order to minimize the complexity of our analysis the difference at another amino acid position (F182, Olfr73;L182, Olfr74) located in the second extracellular loop (ECL2) was not taken into account (Fig. 1c). Before entering into molecular investigations of odorant binding and ...
There have been mixed findings about whether the VWFA shows differential response to words over pictures of objects, with some studies finding such print selectivity (Baker et al., 2007, Kanwisher, 2010, Szwed et al., 2011) and other studies not finding such print selectivity (Kherif et al...
signalling cascades6,33, and phosphopriming could help to enforce the proper order of phosphorylation for specific substrates. Position-specific selectivity for phosphorylated residues for several kinases could be rationalized based on reported kinase domain crystal structures and could be ablated by ...
The lid is a structural and functional determinant of lipase activity and selectivity In several lipases access to the enzyme active site is regulated by the position of a mobile structure named the lid. The role of this region in modulating... F Secundo,G Carrea,C Tarabiono,... - 《Jou...
proposed the supplementary motor area (SMA) as a possible neural basis for motor specificity since neurons in the SMA exhibit both time-interval tuning7 and action selectivity8. A more recent study on monkeys found that neurons in the dorsal frontal regions, including the SMA (pre-SMA and SMA...
Learning specificity was defined as the difference between freezing to CS+ and CS− during memory retrieval sessions (see “Methods”, Eq. (1))3. We used two pure-tone CS stimuli which have been shown to engage AC in both mouse3,12 and human DFC20. The pure tones were close together...