This definition included no significant difference in regression slope in untreated monocytes or during stimulation with the other two pathogens. These criteria found 35 and 20 unique reQTLs, respectively, that became functionally active following A. fumigatus and N. meningitidis exposure. No unique ...
The disease-specific accumulation of pathological proteins has long been the major focus of research in neurodegenerative diseases (ND), including Alzheimer’s disease (AD) and related dementias (RD), but the recent identification of a multitude of genetic risk factors for ND in immune-associated ...
DNA damage response CHK1: Checkpoint kinase 1 DSBs: Double strand breaks PALB2: partner and localizer of BRCA2 CtIP: C-terminal binding protein-interacting protein NSCLC: Non-small cell lung cancer UAF1: USP1 associated factor 1 ZEB1: Zinc finger E-box binding homeobox 1 OC: ...
cluster based on Mendelian randomization77, and another that identified a stronger female-specific effect size forMS4A6A78. Some studies investigating the role of theMS4Afamily suggest mechanisms that involve immune function, particularly among microglia79. While this gene may not have been identified ...
(one-tailed). according to definition 2 , if a gene network was built in such ways that every presented edge was a disease-relevant gene-gene interaction, it was a gene network specific to the disease, a sub-network enriched with pathogenic pathways that lead to the disease. in order to...
since it is mainly limited by the weaker transcriptional variations observed in the H2O2-induced flies. We think that this may be due to a smaller number of cells experiencing stress when flies ingest H2O2. Additional data for comparison with various stress responses (immune stress [24], starvati...
of the models to the experimental data by iteratively changing the value P0 and the activation function fa(t) –as under isometric conditions, the force–length function fl and the force–velocity function fv are close to unit (see Supplementary materials for the definition of these parameters)....
We hypothesized that the apoB-48-only mice would recognize mouse apoB-100 as a foreign antigen and thus would mount a strong immune response if immunized with that protein. In this study, we sought to test that hypothesis and to assess the feasibility of using the apoB-48-only mice to ...
Single cell pseudotime analysis was performed using protein markers for cell type definition. Two methods, Palentir71, and Diffusion pseudotime29 were compared to capture the cell trajectory of B cells inside the GC from protein data. Pseudotime based on single-cell protein marker phenotypes was use...
Guide to Yeast Genetics and Molecular Biology (Academic Press, 1991). Liu, H., Kohler, J. & Fink, G. R. Suppression of hyphal formation in Candida albicans by mutation of a STE12 homolog. Science 266, 1723–1726 (1994). Article CAS PubMed ADS Google Scholar Park, S. O., Frazer,...