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The width of these buckets is analogous to the concept of specific heat capacity. In this analogy, the water being poured into the buckets can be thought of as the heat energy being added to two different materials. The rise in level on the buckets is analogous to the resulting rise in t...
Some of the noted inconsistencies at the gut microbial composition level could be explained by the fact that microbial processes can be performed by multiple different bacteria (i.e., functional redundancy) [9]. Metabolomics analysis could be used to enhance the understanding of the link between ...
Whole chromosome and arm-level copy number alterations occur at high frequencies in tumors, but their selective advantages, if any, are poorly understood. Here, utilizing unbiased whole chromosome genetic screens combined with in vitro evolution to generate arm- and subarm-level events, we iterativel...
We found that all of the groundwater communities are distinct in phylum-level composition (Fig. 1b,c), with a strong divide between the Ag site and the pristine sites on the basis of principal component analysis (Extended Data Fig. 1). Change over time of the Ag groundwater community is...
, with the most variable genes listed at the bottom and the most constant genes at the top of the list. Each row represents the level of expression of a selected key gene. The color of the dot represents the average expression z-score of the cells within the given cluster, while the ...
At the molecular level, T2D islets have a more marked inflammatory status compared to islets exposed to lipotoxicity. The occurrence of inflammation in T2D islets has been previously demonstrated histologically (Marselli et al., 2013; Donath et al., 2013; Marchetti, 2016; Eguchi and Nagai, ...
However, given that the MPP fraction (CD48+CD150−) constitutes the majority of the LSK population, Cebpa downregulation in the LSK fraction (Figure 7B) mainly reflects Cebpa level changes in the MPP population. Given that C/EBPα negatively regulates cell cycle genes to keep a constant ...
the variant-to-function mapping nominated a total of 699 putative cell type-specific regulatory variants underlying the predisposition to acquiring complex traits and diseases. In addition, 672 genes correlated with the variants were reported to affect the biology relevant to the corresponding phenotypes...
The usefulness of hybridization-based rRNA depletion depends strongly on its specificity, since cross-hybridization of rRNA probes to other transcripts will result in incorrect transcript level measurements. To determine whether the set of 12 biotinylated probes designed for this study cross-hybridized wit...