An Example of Specific AIMS in NIH StyleSchlumberger, ESuiro, LDeborde, a S
Reliable reference data in medical imaging is largely unavailable. Developing tools that allow for the comparison of individual patient data to reference data has a high potential to improve diagnostic imaging. Population atlases are a commonly used tool
This study had 3 aims: (1) to develop and refine the construct of diagnostic pitfalls, (2) to collect a list of disease-specific examples of diagnostic pitfalls, and (3) to analyze these disease-specific pitfalls to create a taxonomy of generic types of diagnostic pitfalls occurring in ...
for identification of CNAs, HATCHet2’s model aims simply to group bins into copy-number states, unlike existing approaches which aim to concurrently infer the underlying integer copy numbers [24,29,68,69,70,71]. The fifth and final step of HATCHet2 infers integer-valued haplotype-specific cop...
Neurons in the posterior parietal cortex contribute to the execution of goal-directed navigation1and other decision-making tasks2,3,4. Although molecular studies have catalogued more than 50 cortical cell types5, it remains unclear what distinct functions they have in this area. Here we identified...
with all{\rho }_{jk}=0. Of note, as the detection of genetic effects is always much harder in less abundant cell types, the incorporation of the estimated genetic correlation aims to improve the power in the less abundant cell types by borrowing information from the more abundant cell ...
The intention is to locate the potential protein-altering variants underpinning the association between 176 genetic loci sieved from the NIH GWAS catalog (http: //www.genome.gov/gwastudies)18 with either eye-related traits such as corneal curvature (CC), central corneal thickness (CCT), corneal ...
However, S2B approaches this problem from a different perspective, as it aims to identify individual proteins that are directly involved in the mechanisms of both diseases simultaneously. We applied S2B to Amyotrophic Lateral Sclerosis (ALS) and Spinal Muscular Atrophy (SMA), two fatal Motor Neuron...
Different from PRIAM, BrEPS aims at defining minimal sequence patterns for one or more EC numbers. In the first step the enzyme sequences in the Swiss- Prot part of the UniprotKB are identified and sorted into three categories. The enzyme sequences are then compared by an all-vs.-all ...
still come to light, independently of the total expression (that may remain unaffected). Currently much of the research effort in biology focuses on generation of large, comprehensive genome wide datasets, such as ENCODE project. One of the aims of such efforts is being able to look for ...