The presence of a number of chromosomal biotypes indicates that such aneuploid numbers often arise. Minor differences in details of chromosome morphology, and the presence of super-numerary constrictions in certain species, have been regarded as proving that structural changes of chromosomes have also...
Both frequency and patterns of LOH differed greatly between the two tumor types. Although LOH was frequently detected in the special variant tumors, it was rare in the usual type tumors. LOH was detected in only 8 of the 18 usual tumors, with chromosomes 17, 13, and 2 being the most ...
"For the first time, we see that the structure of the chromosomes contributes to gene control," says Whitehead Member Richard Young, who is also a professor of biology at MIT. "In the past, there have been all kinds of ideas around how the structure might affectgene control, but now one...
To the extent that one is claiming that genomes are body parts that can be owned, one might more properly say that people own their chromosomes just as they own their livers. Yet when a person says, "I own my genome," he or she is not talking about owning these subcellular structures,...
Sparse canonical correlation analysis performed by chromosome shows that copy number changes in chromosomes 2, 12, and 15 each show significant correlation (p≤0.05) with sets of gene expression changes. Immunohistochemistry is performed for 6 markers that were highly expressed in the muscle-enriched ...
Chromosomal disorders is the result of abnormalities with one of the 23 pairs of chromosomes. This can include an extra chromosome such as Down syndrome or a deletion in the chromosome. Neurodevelopmental Neurodevelopmental disorders are a group of disorders that affect the brain and the nervous syst...
The somatic chromosomes, obtained from short term leukocyte cultures, were studied of four species of the Hylobatidae: Hylobates lar, H. agilis, H. (Nomascus) concolor and Symphalangus syndactylus. In accordance with earlier observations by others, the diploid chromosome numbers were found to ...
Wimmer K et al (2006) Spectrum of single- and multiexon NF1 copy number changes in a cohort of 1,100 unselected NF1 patients. Genes Chromosomes Cancer 45(3):265–276 Article CAS PubMed Google Scholar Eaton KW et al (2011) Spectrum of SMARCB1/INI1 mutations in familial and sporadic ...
-b N2-like.pools -m 6516557 -c N2-like.trunc.tag.pileup.uniqlocs.all.csv -r N2-like.trunc.tag.pileup.uniqlocs.all.rpt -p N2-like.trunc.tag.pileup.uniqlocs.all.prop rad_locus_perfect_matches.pl -f Gasterosteus_aculeatus.BROADS1.66.dna.chromosomes.SbfI.fragments.txt -l 49 -e CC*...
as were individuals with neither XX nor XY chromosomes. Finally, individuals with more than 10 putative third degree relatives (identified by Bycroft et al. [25] by estimating the kinship coefficients for all pairs of samples using the software KING [30]) were also removed. This left 408,095...