Recent breakthroughs in cellular omics technologies have paved new pathways for understanding the regulation of genomic elements and the relationship between gene expression, cellular functions, and cell fate d
Spatiotemporal omics for biology and medicine 2024, Cell Show abstract Multiscale engineering of brain organoids for disease modeling 2024, Advanced Drug Delivery Reviews Citation Excerpt : Each of the six cortical layers is developed through temporally controlled morphological and migratory processes [81...
Furthermore, it can also be used for studying the 3D tissue structures across the whole regeneration process of the planarian. Fig. 1: The four-dimension spatiotemporal transcriptomic cell atlas of planarian Schmidtea mediterranea. a Overview of the study design for multi-omics atlas of planarian ...
Methods for the analysis of cell secretions at the single-cell level only provide semiquantitative endpoint readouts. Here we describe a microwell array for the real-time spatiotemporal monitoring of extracellular secretions from hundreds of single cells
methodologies. Consequently, the integration of spatiotemporal multi-omics approaches emerges as a transformative avenue for untangling the intricacies inherent to aging and regeneration. This, in turn, fosters a fertile ground for the cultivation of innovative therapeutic strategies poised to shape the ...
By applying Stereo-Seq research on the leaf cells of theArabidopsisplant, the researchers were able to overcome the long-term difficulty for researchers to conduct spatially-resolved single-cell omics studies on leaves and other plant tissues. BGI Research was able to demonstrate that Stereo-Seq te...
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Table 2 Representative spatially resolved methods of metabolomics and metabolic regulomics for analyzing cancer immunity Full size table The next-generation PET imaging system, designed for characterizing cancer immunometabolism, has seen improvements in two key areas: (i) Optimization of tracers The cur...
Lipidomics Peroxisomes Proteome Main Living organisms have evolved the capacity to store energy in the form of fat in lipid droplets (LDs). The core of these storage organelles contains neutral lipids, such as triglycerides, and an average healthy adult stores 10–25 kg of fat primarily in ...
Table 2 Representative spatially resolved methods of metabolomics and metabolic regulomics for analyzing cancer immunity Full size table The next-generation PET imaging system, designed for characterizing cancer immunometabolism, has seen improvements in two key areas: ...