We conducted an in-depth investigation into the potential alterations of microglia density and morphological complexity using IBA1+cells from the cingulate cortex of elderly individuals diagnosed with cSVD (Fig.1), which showed white matter lesion (WML) as well as hyalinosis of vessels and enlarged...
In current research, understanding the dynamics of tumor-associated macrophages (TAMs) within the intricate context of the tumor microenvironment (TME) has become paramount. The TME constitutes the immediate surroundings where tumors thrive, encompassing blood vessels, stromal cells, immune cells, and a...
Rapid temporal dynamics of transcription, protein synthesis, and secretion during macrophage activation. Mol. Cell. Proteomics 13, 792–810 (2014). CAS PubMed PubMed Central Google Scholar McGourty, K. et al. Salmonella inhibits retrograde trafficking of mannose-6-phosphate receptors and lysosome ...
The right panel: Proportions of different macrophage types in the IZ region of mice 48 h and 4 weeks after MI. F, Developmental trajectory analysis of monocytes and macrophages in the IZ region after MI (Monocle3), with Ly6c2hi monocytes set as the trajectory root; the scale represents ...
Overall, these strategies enable the non-targeted acquisition of metabolomes or transcriptomes from single living cells, and hold immense promise for future investigations into the temporal dynamics of TME metabolism. (Fig.4a; Table1). However, they face technical challenges, such as analyzing samples...
Spatiotemporal dynamics of optical molecular motors The spatiotemporal dynamics of optical molecular motors is simulated on the basis of a spatially resolved model. A spatially dependent Fokker-Planck model ... E Gehrig,O Hess - 《Physical Review E Statistical Nonlinear & Soft Matter Physics》 被...
Overall, these strategies enable the non-targeted acquisition of metabolomes or transcriptomes from single living cells, and hold immense promise for future investigations into the temporal dynamics of TME metabolism. (Fig.4a; Table1). However, they face technical challenges, such as analyzing samples...
Combining large-scale approaches, we examined the spatio-temporal dynamics of 28 different immune cell types (immunome) infiltrating tumors. We found that the immune infiltrate composition changed at each tumor stage and that particular cells had a major impact on survival. Densities of T follicular...
we quantifed the fraction of scar-resident cells and proposed four possible phases of scar formation:macrophage infltration,proliferation and diferentiation of scar-resident cells,scar emergence,and scar stationary.Together,these profles delineated the spatial heterogeneity of the scar,confrmed the ...
We suggest that this pro/anti-inflammatory switch is a simple program that helps ensure the resolution of inflammation. To examine this idea, we have developed a microsimulation model in which individual leukocytes with non-trivial internal dynamics move in three-dimensional tissues and interact with...