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In respiratory research, the cell atlas identifies previously undefined cell catalogues and their phenotypes and interactions, enhancing our understanding of respiratory and lung diseases [73, 74]. Combined with scRNA-seq, many studies have generated lung molecular cell atlases of health and disease, ...
We use this high-resolution spatial map to characterize fundamental steps in the patterning of the midbrain–hindbrain boundary (MHB) and the developing gut tube. We uncover axes of cell differentiation that are not apparent from single-cell RNA-sequencing (scRNA-seq) data, such as early dorsal...
Application scenarios of spatial transcriptomics. “Tissue Architecture” refers to studies that elucidate the spatial distribution of cell subpopulations in a specific tissue and decode intercellular interaction. “Tissue Development” represents research into resolving morphogenesis patterns and spatiotemporal ge...
Background Despite a growing pipeline of effective clinical treatments, there remains a persistent research-to-practice gap in drug abuse services. Delive... LJ Ducharme,RK Chandler,TRA Wiley - 《Health & Justice》 被引量: 30发表: 2013年 Private Security in Guatemala: Pathway to Its Proliferatio...
Fresh-frozen OSCC tissue was obtained from the Alberta Cancer Research Biobank under the approval of the Health Research Ethics Board of Alberta – Cancer Committee (Study ID: HREBA.CC-16-0644). Informed consent for tissue collection and research was obtained from each patient. No participant ...
BMC Public Health Home About Articles Submission Guidelines Collections Join the Editorial Board Submit manuscript Research article Open access Published: 03 March 2023 Spatial associations of long-term exposure to diesel particulate matter with seasonal and annual mortality due to COVID-19 in ...
A tumour is a product of somatic evolution in which mutation, selection, genetic drift and cell dispersal generate a patchwork of cell subpopulations (clones) with varying degrees of aggressiveness and treatment sensitivity1. A primary goal of modern cancer research is to characterize this evolutionary...
changes in the cell composition of the tissue, which in turn increases the risk of developing insulin resistance, type 2 diabetes, and other cardiometabolic complications2. Defining the cellular landscape and microarchitecture of human WAT in health and disease is therefore of considerable clinical ...
The kernel density was used to identify the spatial hotspots of the CGBPs distribution in this research. 2.3.3 Standard deviational ellipse The standard ellipse is a classic spatial distribution analysis algorithm that examines the characteristics of a point data set. The long axis of the ellipse ...