Some of our favorite Visium spatial transcriptomics publications from 2023 From identifying a previously undescribed T-cell state in cancer, to defining the genes involved in healthy palate development, these publications cover the most innovative and interesting applications of the Visium Spatial platform...
Spatial transcriptomics technologies are assessed by key metrics, such as resolution of the spatial biology, gene plexity (the number of genes detected), and gene sensitivity (the linear dynamic range of accurate transcript detection). 10x Genomics spatial tools are optimized to provide robust insight...
Visium is based on the Spatial Transcriptomics technology which was first reported in 2016. Since then Visium data has been published in nearly 90 peer-reviewed articles, including journals from Nature, Cell, and Science. Internally, over 30 different fresh frozen tissues and FFPE tissues have been...
该论文的通讯作者Joakim Lundeberg也是瑞典Spatial Transcriptomics公司的联合创始人之一,2018年底10X Genomics宣布收购Spatial Transcriptomics,并于2019年发布Visium空间基因表达解决方案(Visium Spatial Gene Expression Solution)。 02、10X Genomics Visium空间转录组技术 1、技术原理 将冰冻组织切片放置在10X Genomics Visium芯...
该论文的通讯作者Joakim Lundeberg也是瑞典Spatial Transcriptomics公司的联合创始人之一,2018年底10X Genomics宣布收购Spatial Transcriptomics,并于2019年发布Visium空间基因表达解决方案(Visium Spatial Gene Expression Solution)。 02、10X Genomics Visium空间转录组技术 ...
对于两年以上的甲醛固定石蜡包埋(FFPE)样本,选择哪种空间转录组测序(Spatial transcriptomics)技术取决于几个关键因素,包括样本的保存状态、研究目的和可用技术的特点。[1] 下面简要分析几种主流技术的适用性: 1. NanoString GeoMx DSP: - 优点:NanoString的GeoMx Digital Spatial Profiler非常适合于FFPE样本,因为它不依...
近日,10x Genomics公司宣布收购位于瑞典斯德哥尔摩的Spatial Transcriptomics公司。Spatial Transcriptomics公司是空间基因组学(spatial genomics)领域的领先公司。空间基因组学是一个新兴领域,它不但让研究人员可以获得单细胞内的基因组数据,而且可以比较在组织不同部位的细胞中基因组信息的变化。这一技术在肿瘤学、神经科学...
这项技术的通讯作者Joakim Lundeberg也是瑞典Spatial Transcriptomics公司的联合创始人之一。2018年底，10X Genomics宣布收购Spatial Transcriptomics，并于2019年发布Visium空间基因表达解决方案。Visium空间转录组技术采用独特的技术原理，将冰冻组织切片放置在芯片的捕获区域内，通过HE染色和成像后进行透化处理，释放...
Spatial transcriptomics was performed with the Visium Spatial Gene Expression platform from 10x Genomics. Harvested plant roots were rinsed with deionized H2O and cryopreserved in optimal cutting temperature compound via submerging of optimal cutting temperature-embedded molds into a dewar of isopentane chill...
Spatial transcriptomics represents a state-of-the-art profiling technique that enables the sequencing of total mRNA in fresh frozen tissues while simultaneously mapping these transcripts to their corresponding tissue positions using unique barcodes to identify spatial gene expression patterns. The first spat...