Elongated hypocotyl5 (HY5) is a key transcription factor that promotes photomorphogenesis. Constitutive photomorphogenic1 (COP1)-Suppressor of phytochrome A-105 (SPA) E3 ubiquitin ligase complex promotes ubiquitination and degradation of HY5 to repress photomorphogenesis in darkness. HY5 is also ...
在光信号传导通路中,拟南芥COP1(constitutive photomorphogenesis 1)位于多种光信号下游,作为整合点抑制光形态建成,同时也受光信号负调控而失活.在分子水平上,COP1作为一个E3泛素连接酶,通过介导促进光形态建成的一些正调控转录因子(比如HY5,LAF1和HFR1)以及光受体(比如光敏色素A和隐花色素2)的蛋白降解来...出版...
在光信号传导通路中,拟南芥COP1(constitutive photomorphogenesis1)位于多种光信号下游,作为整合点抑制光形态建成,同时也受光信号负调控而失活.在分子水平上,COP1作为一个E3泛素连接酶,通过介导促进光形态建成的一些正调控转录因子(比如HY5,LAF1和HFR1)以及光受体(比如光敏色素A和隐花色素2)的蛋白降解来行使负调摔...
有趣的是,HY5过表达并不会增强光形态建成表型,而黑暗条件下的HY5过表达也不会引起去黄化【3】,并且HY5蛋白中缺少反式激活结构域,这意味着COP1-HY5调控模块中包含未知X因子,并且该因子具备以下特征:①受到COP1的负调控且功能上依赖于HY5;② x突变体与hy5突变体表型一致并且X过表达会导致超光形态建成。 根据...
One characteristic phenotype of the COP1-SPA- related mutants is premature light-induced development even in the absence of light called constitutive photomorphogenic (cop) development11. This is because COP1-SPA complex targets positively acting transcription factors (e.g., HY5/LAF1/HFR1 and ...
However, in both of these cases, SPA1 acts as a stabilizer whereas in high temperatures, phosphorylated PIF4 and HY5 are more stable and regulate downstream genes responsible for morphological changes in seedlings37. Recently, COP1 was reported to negatively regulate protein translation in the ...
在光信号传导通路中,拟南芥COP1(constitutive photomorphogenesis1)位于多种光信号下游,作为整合点抑制光形态建成,同时也受光信号负调控而失活.在分子水平上,COP1作为一个E3泛素连接酶,通过介导促进光形态建成的一些正调控转录因子(比如HY5,LAF1和HFR1)以及光受体(比如光敏色素A和隐花色素2)的蛋白降解来行使负调摔...
Molecular Interaction between COP1 and HY5 Defines a Regulatory Switch for Light Control of Arabidopsis Development Arabidopsis COP1 acts as a light-inactivable repressor of photomorphogenic development, but its molecular mode of action remains unclear. Here, we show that COP1 negatively regulates HY...
SPA1 is a kinase-like coiled-coil/WD-repeat protein that interacts and activates the E3 ubiquitin ligase activity of COP1 [6, 10, 11]. Given the known function of SPA1 in light signal transduction, we conducted a detailed investigation of the CRY2-SPA1 interaction. We first examined and...
One characteristic phenotype of the COP1-SPA-related mutants is premature light-induced development even in the absence of light called constitutive photomorphogenic (cop) development11. This is because COP1-SPA complex targets positively acting transcription factors (e.g., HY5/LAF1/HFR1 and ...