Figure 3. Substrate scope of the three-component azinylic C(sp3)-H bond functionalization (图片来源:Chemical Science) 通过改变反应条件,这种实用的瞬态活化策略已经被应用于α,β-不饱和烯烃的双官能化(Figure 3)。在此之前,涉及缺电子杂苄基C(sp 3 )-H键的活化和氟烷基自由基加成的Giese反应很少被报道。
Dixneuf, Pierre HBruneau, ChristianSpringer International PublishingBruneau, C. sp3 C-H bond functionalization with ruthenium catalysts. In Ruthenium in Catalysis; Dixneuf, P.H., Bruneau, C., Eds.; Springer: Berlin, Germany, 2014; Chapter 6, pp.195-236....
Sp3C-HBondActivationCatalyzedbyTransitionMetalReporter:WanXiaobingSupervisor:Prof.ShiZhangjie2Academic:highbondenergyPractical:abundant,cheap,clean3CnH2n+2Cl2hvCnH2n+2-mClmCnH2n+2combustionCO2+H2OCnH2n+2RN=NRO2,Me3CO2HCnH2n+1OOH4Themainchallengefacingalkanetransformationisselectivity,notreactivity5...
在温和条件下将甲烷直接转化为高附加值产品是化学、能源和环境的理想目标。在温和条件下,光催化反应体系中产生的活性物质可以活化甲烷中惰性的C-H键,促进甲烷转化。近日,国家纳米科学中心唐智勇研究员团队在CCS Chemistry发表综述文章,重点...
The selective formation of carbon–carbon bond by functionalization of an sp 3 C–H bond is still a challenge in organic synthesis. There are already examples involving transition metal catalysis. In this chapter we review the use of ruthenium(0) and ruthenium(II) catalysts for the formation of...
近日,德国亚琛工业大学的Long Huang与沙特阿卜杜拉国王科技大学的Magnus Rueping教授课题组报道了一种光/镍协同催化下立体发散性烯丙基C(sp3)-H键芳基化反应。该催化反应通过配体调控空间效应以及电子效应来实现烯丙基C(sp3)-H键芳基化过程中的Z/E选择性,理论计算结果表明Ni-烯丙基物种由单重态激发至三重态时导致...
C–H bonds of feedstock chemicals without the need for substrate pre-activation. These reactions have traditionally relied on precious-metal catalysts for C–H bond cleavage and, as a result, display high selectivity for borylation of aromatic C(sp2)–H bonds over aliphatic C(sp3)–H bonds. ...
(Amide-directed photoredox-catalysed C–C bond formation at unactivatedsp3C–H bonds.Nature,2016, DOI: 10.1038/nature19810; Catalytic alkylation of remote C–H bonds enabled by proton-coupled electron transfer.Nature,2016, DOI: 10.1038/nature19811)。
采用结合了N-中心自由基(NCR)的Cu(ii)双齿配体作为调控HAT的试剂,能够放大如烯丙基等复杂分子中C-H键的位点选择性。 文献信息:Site-specific allylic C–H bond functionalization with a copper-bound N-centred radical, (Nature,2019,DOI: 10.1038/s41586-019-1655-8) [原文链接]...
long huang*, marcin szewczyk, rajesh kancherla, bholanath maity, chen zhu, luigi cavallo*, magnus rueping*. modulating stereoselectivity in allylic c(sp 3 )-h bond arylations via nickel and photoredox catalysis. nat....