But here, anomalous behavior was observed as nucleophilic 5-C atom of 2-aminothizole reacts regioselectively with carbonyl group of isatin and gave 3-hydroxy indoles. The finding demonstrates significant product yields of 3-hydroxy indoles, which are highly beneficial building blocks for the ...
In 2015, Kitamura reported the intramolecular Rh‐quinoid carbene C(sp2)−H insertion reaction of 3‐aryloxycarbonyldiazonaphthoquinones catalyzed by Rh2(oct)4 to give a series of β‐phenylnaphthalene lactones (up to 20 examples) in yields as high as 92 % (Scheme 6).[36] Since the ...
Here, we describe our research of carbonyl-directed stepwise double arylation of 1,1-disubstituted olefins, via a sequential Mizoroki-Heck,E/Zisomerization and C–H activation (3 steps in 2 pots), implementing the modular synthesis of stereodefined 1,1,2-triarylated all-carbon tetrasubstituted ole...
Ketones are widely present in natural products and synthetic molecules, and are one of the most fundamental feedstocks in organic synthesis. But while there are many reactions involving the α-functionalization and transformation of carbonyl group of ketones, the selective and catalytic cleavage of C(...
Considering silver is the heavier congener of copper in the Periodic Table and it also has high catalytic activity for C–H functionalization, we speculated that the DMEDA directing group may facilitate the silver-mediated methoxylation of aryl C(sp2)–H bonds. We found that this is indeed the...
The authors also mentioned that iodonium species could act as Lewis acids in association with an activation of the carbonyl group of coumarin. In the coordinating DMF solvent, an oxidative attack at the C4 position with a synergetic activation of the vicinal C–H bond of coumarin formed aryl...
A Theoretical Study of Cyclohexyne Addition to Carbonyl-C(alpha) Bonds Allowed and Forbidden Electrocyclic and Nonpericyclic Ring-Openings of Strained Cyclobutenes 热度: 国债逆回购的最全资料(The most comprehensive data of reverse repurchase of treasury bonds) ...
Among these, the weakly coordinating nitrile group has attracted much attention because it is a transformable, easily installed and readily removed directing group, which can be easily converted into a number of different functional groups, such as carboxyl, carbamoyl, aminomethyl, carbonyl, and ...
Amide-Directed Alkenylation of sp2 C-H Bonds Catalyzed by a Cationic Rh (Ⅰ)/BIPHEP Complex Under Mild Conditions: Dramatic Rate Acceleration by a 1-Pyrrolidinecarbonyl Group. Shibata Y,Otake Y,Hirano M, et al. Organic Letters . 2009
carbonyl sp 2 C-H bondMizoroki-Heck coupling reactionoxidation processtransition-metal catalystsAn oxidation of alkenyl sp2C-H bonds can be established through multiple steps, and transition-metal catalysts are normally necessary to complete the functionalizations of these C-H bonds, such as in the...