The invention belongs to the technical field of biology, relates to a lung tissue specific SP-C promoter and an application of the promoter, and particularly provides a specific promoter within a lung tissue specific expression gene 5' control region and an application of the promoter to a ...
Using intratracheal delivery of DNA followed by electroporation, we demonstrate that the SP-C promoter sequence will enhance gene expression specifically in ATII cells in mouse lung. This represents a new activity for the SP-C promoter, and thus ATII cell-specific nuclear import of DNA may prove...
Abstract A 1.277 kb promoter fragment of the gene encoding one of the lung surfactant proteins, SP-C, was cloned from a human genomic library and characterized using the human α1-proteinase inhibitor (α1PI) gene as reporter. Messenger RNA for human α1PI isolated from a single transgenic ...
Pleomorphic adenoma gene like-2 (PLAGL2), a previously identified TTF-1-independent activator of the SP-C promoter, was not down-regulated, nor increased, within those cells. Its cellular location was redistributed from the cytoplasm to the nucleus. Chromatin immunoprecipitation (ChIP) and ...
背景:携带巨噬细胞特异性启动子SP146-C1(Synthetic promoter 146-C1)及外源性基因血管内皮生长因子C(vascular endothelial growth factor C,VEGFC)的重组9型腺相关病毒(recombinant adeno-associated virus serotype 9,rAAV9)在动脉粥样...
Catalyst 8a has also been shown as a effective promoter for the sila-Sonogashira coupling between 1-(trimethylsilyl)alkynes and aryl iodides and bromides in the presence of CuI or Bu 4 NBr as co-catalysts. This complex also catalyzes efficiently the homocoupling reaction (Glaser-type coupling) ...
Site-directed mutagenesis was performed to get the SP-C gene promoter mutant(SP-CP-mComclu) and PLAGL2 mutants(PLAGL2-mF6,PLAGL2-mF7);EMSA was performed to identified the ability and specifity of interaction between PLAGL2 or it′s mutant and SP-C gene promoter DNA fragment or it s mu...
Obesity is also a main concern associated with expanded morbidity and mortality from many noncommunicable illnesses (NCDs). The study aimed to determine the antiobesity effect of Pleurotus ostreatus (PO) and its bioactive anthraquinone (AQ). The overall promoter genes CEBPα (CCAAT enhancer binding ...
bai gene cluster is controlled by a single promoter and produces a single polycistronic mRNA [60,61], it appears that the bai genes of c-25 are separated into multiple gene clusters that are presumably transcribed from different promoter sites (see Table S4 for promoter prediction information)....
简要介绍了SP促销的含义与特点,以及在市场经济条件下对商业企业经营所产生的功效,并对商业企业SP促销计划与促销策略的制定做了具体阐述。 更多例句>> 2) plan and urges sale 策划与促销 例句>> 3) design promoter 设计促销商 4) sale plan 销售计划 ...