As a prerequisite to this function, Sox9 protein must be present in Col10a1-expressing chondrocytes. Using RNA in situ hybridization, we confirmed (Lefebvre et al., 1998) that Sox9 and Col10a1 RNAs overlap each other in prehypertrophic cells, and immunostaining revealed that the Sox9 protein ...
Skip to main contentSkip to article
However, the utilization of SOX9 as a biomarker for other urological cancers has not yet been investigated. In the present study, paired patient tissue microarrays were analyzed by immunohistochemistry, and the SOX9 protein expression was quantitated as immunoreactive scores in patients with renal cell...
Distinctive structures called crypts harbor intestinal epithelial stem cells (IESCs) which generate progenitor and terminally differentiated cells in the intestinal epithelium. Mammalian IESCs and their daughter cells require the participation of DNA met
3E, SOX9, but not JUN, caused a significant change in the luciferase activity of the TSPAN8 promoter-reporter construct, indicating that SOX9 might regulate TSPAN8 transcription. The mRNA and protein expression levels of SOX9 were further found to increase upon EGF treatment but were reduced by ...
Recombinant protein Gene ID 6662(Human); 20682(Mouse) SwissProt P48436(Human); Z(Mouse) Synonyms CMD1; CMPD1; SRA1 Category Stem Cells & Wnt; Epigenetics Background Sox genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain...
As the full-length GST-Sox9 fusion protein is unstable and readily broken down in bacteria (not shown), we tested whether Sox9 was directly phosphorylated at serine 181 by AKT using a GST-Sox91-223 truncation. Recombinant AKT was able to efficiently phosphorylate the GST-Sox91-223 fusion ...
The contribution of Sox9 to post natal growth and maturation of the valve is not known, but this study provides insights for future work examining the differential functions of Sox9 protein in valve cell populations. Anat Rec, 302:108–116, 2019. ? 2018 Wiley Periodicals, Inc.Donika Gallina...
protein play an important role in inhibiting tumor metastasis. The low expression of NM23 is closely correlated with the metastasis and poor prognosis of lung cancer, melanoma, breast cancer and other tumors (19–21). The present study revealed that silencing NM23 gene in PC cells could lead ...
For example, mRNA expression does not always result in subsequent protein expression and protein expression does not always correspond to protein activity [5]. Secondly, although these methods provide effective qualitative and quantitative information on gene and protein expression, information on ...