Sox9基冈修饰人脐带间充质千细胞向软骨细胞分化的实验研究 中文摘要 Sox9基因修饰人脐带间充质千细胞向软骨细胞分化的 实验研究 中文摘要 目的:构建人Sox9基因慢病毒载体,体夕iSox9慢病毒载体转染人脐带问充质干细 基因修饰的hUC.MSCs在单层培养条件下向软骨细胞分化的能力,为软骨组织损伤及 退变性疾病的细胞学及基...
Up-regulation of SOX9 in human sex-determining region on the Y chromosome (SRY)-negative XX males. Yoshiyuki Kojima,Yutaro Hayashi,Kentaro Mizuno,Shoichi Sasaki,Yuko Fukui,Peter Koopman,Ken-Ichiro Morohashi,Kenjiro Kohri. Clinical Endocrinology . 2008...
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 理论分子量;56kDa 细胞定位;细胞核 性状;Liquid 浓度;1mg/ml 免疫原;KLH conjugated synthetic peptide derived from human SOX9: 351-450/509 ...
苏州大学硕士学位论文Sox9基因修饰人脐带间充质干细胞向软骨细胞分化的实验研究姓名:***学位级别:硕士专业:外科学(骨科)指导教师:**201105Sox9基冈修饰人脐带间充质千细胞向软骨细胞分化的实验研究中文摘要Sox9基因修饰人脐带间充质干细胞向软骨细胞分化的实验研究中文摘要目的:构建人Sox9基因慢病毒载体,体夕['Sox9慢病...
摘要: 性反转综合征是一种性别发育异常的遗传性疾病,主要表现为性腺性别与遗传性别相反.SRY,SOX9,DAX-1在性别决定中起着重要的作用,它们的异变可以导致不同类型的性反转发生.本文对这3个基因的结构,功能以及引起性反转可能的分子遗传学机制进行综述. 展开 关键词: 性反转综合征 SRY基因 SOX9基因 DAX-1基因 分子...
Background In human embryogenesis, loss of SRY (sex determining region on Y), SOX9 (SRY-related HMG box 9) or SF1 (steroidogenic factor 1) function causes disorders of sex development (DSD). A defining event of vertebrate sex determination is male-specific upregulation and maintenance of SOX9...
The transcription factor Sox9 was first discovered in patients with campomelic dysplasia, a haploinsufficiency disorder with skeletal deformities caused by dysregulation of Sox9 expression during chondrogenesis. Since then, its role as a cell fate determiner during embryonic development has been well charact...
As expected, the activity of the Col10a1 promoter was upregulated in primary chondrocytes when the reporters contained the Col10a1 hypertrophic enhancer and the cells were treated with okadaic acid (Figure 4A). Forced expression either human SOX9 or mouse Mef2c enhanced transactivation, and forced...
Chromosomal translocations in individuals with both syndromes had localized an autosomal sex reversal locus (SRA1) and a campomelic dysplasia locus (CMPD1) to the long arm of human chromosome 17. The molecular cloning of a translocation breakpoint in a sex reversed campomelic dysplasia patient ...
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 产品介绍Plays an important role in the normal skeletal development. May regulate the expression of other genes involved in chondrogenesis by acting as a transcripti...