该基因编码的蛋白质与hmg盒类dna结合蛋白的其他成员一起识别ccttgag序列。它在软骨细胞分化过程中起作用,并与类固醇生成因子1一起调节抗米勒氏激素(amh)基因的转录。缺陷导致骨骼畸形综合征-畸形-畸形-畸形,常伴性反转。 The protein encoded by this gene recognizes the sequence CCTTGAG along with other members...
1.Mutation analysis of SOX9 gene in patients with hypospadias;尿道下裂患者SOX9基因突变的研究 2.Effects of Sox9 gene mediated by adenovirus on lumbar intervertebral degenerative disc of rabbits;腺病毒介导的Sox9基因对兔退变腰椎间盘的治疗作用 3.Sox9 gene therapy for intervertebral degenerative disc of ...
Gene SummaryThe protein encoded by this gene recognizes the sequence CCTTGAG along with other members of the HMG-box class DNA-binding proteins. It acts during chondrocyte differentiation and, with steroidogenic factor 1, regulates transcription of the anti-Muellerian hormone (AMH) gene. Deficiencies...
该基因编码的蛋白质与hmg盒类dna结合蛋白的其他成员一起识别ccttgag序列。它在软骨细胞分化过程中起作用,并与类固醇生成因子1一起调节抗米勒氏激素(amh)基因的转录。缺陷导致骨骼畸形综合征-畸形-畸形-畸形,常伴性反转。[由RefSeq提供,2008年7月] The protein encoded by this gene recognizes the sequence CCTTGAG...
【关键词】椎问盘;遗传载体;干细胞;SOX9基因ConstructionoflentiviralvectorcontainingSOX9geneanditsexpressioninboneIIlRIWOWmesenchymalstemcellsX￡,Yua,CHENLiang,ZHUXue—song,SHIQin,U￡/yo昭,G“yong,弼ⅣGTian-si.DepartmentofOrthopedics,FirstAp2池eHospital。SoochowUniversi*y,Suzhou215006,ChinaCorrespondingauthor:...
SOX9 gene transfer via safe, stable, replication-defective recombinant adeno-associated virus vectors as a novel, powerful tool to enhance the chondrogenic potential of human mesenchy- mal stem cells. Stem Cell Res Ther 2012;3:22.Venkatesan, J.; Ekici, M.; Madry, H.; Schmitt, G.; Kohn...
In addition, functional study of these enhancers could shed light on the mechanismof regulating SOX9 gene expression and disease development.[Keywords] SOX9; enhancer; cartilage development; craniofacial development; sex determination[ 综述 ]作为 SOX 家族的成员,转录因子 SOX9 通过激活细胞干性基因、调控...
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Sox9基因表达及其在猪未成熟支持细胞中的作用研究.pdf,摘要摘要 Sox9 基因是哺乳动物睾丸决定基因SRY 的主要靶基因,位于雄性Y 染色体上。在 哺乳动物中,Sox9 已被证明在雄性性别决定、睾丸发育和支持细胞分化等过程中发挥 关键作用。支持细胞作为输精管内独特的体细胞
Bonemarrowsamplesobtainedfromaborted6-monthhumanfetalfemurwerewashedwithphosphate-bufferedsalineandthecellularfractionwasrecoveredbycen2trifugation.ThecellswereloadedontoaPercolllayeratadensityofdensity1.073g/mlandcentrifugedat1100gfor30min.Full-lengthcDNAofhumansox9genewasinsertedintothemultiple-cloningsiteofpcDNA3.1...