High expression of SOX21-AS1 was associated with poor overall survival. Silencing of SOX21-AS1 restrained cell proliferation, migration, invasion, and increased apoptosis in HEC-1A and Ishikawa cells. Additionally, bioinformatics analysis demonstrated that SOX21-AS1 modulated RAF1 expression by ...
目的探讨长链非编码RNA(long non-coding RNA,lncRNA) SOX21-AS1及SOX21在宫颈癌中的表达及其临床意义。 方法收集宫颈脱落细胞学标本共43例,其中正常23例,宫颈癌20例。采用实时定量聚合酶链反应( real-time quantitative polymerase chain reaction,qRT-PCR)检测所有标本中SOX21-AS1及SOX21的表达水平,分析SOX21-AS1...
Hypomethylation of the lncRNA SOX21-AS1 has clinical prognostic value in cervical cancer (2019).[10.1016j.lfs.2019.116708] Contents lists available at ScienceDirectLife Sciencesjournal homepage: www.elsevier.com/locate/lifescieHypomethylation of the lncRNA SOX21-AS1 has clinical prognostic value incerv...
SOX21-AS1miR-145MYO6Emerging evidences have proved that long non-coding RNAs (lncRNAs) act as important molecular regulator in the tumor progression, including colorectal cancer (CRC). LncRNA SOX21-AS1 has been verified as oncogenic molecular in other cancers and tumorigenesis. In present study,...
目的 探讨SOX21反义RNA1(SOX21-AS1)在非小细胞肺癌(NSCLC)组织中的表达及临床意义.方法 收集本院2014年9月至2017年6月手术切除的NSCLC患者癌组织和配对癌旁组织94对,采用实时定量PCR( QPCR)检测上述组织中的SOX21-AS1水平,分析其与NSCLC临床病理特征(性别,年龄,吸烟史,肿瘤大小,淋巴结转移,TNM分期和病理类型)...
Conversely, the use of small interfering RNA to inhibit the expression of SOX21-AS1 yielded the opposite results (P<0.01). SOX21-AS1 functions as an oncogenic LncRNA which enhances CC cell metastasis, invasion and proliferation through FZD3 upregulation via Wnt/尾-catenin-signaling pathway ...
Objective: To analyze the expression of cerebrospinal fluid exosome microRNA-204-3p (miR-204-3p) and serum exosome long-chain non-coding RNA cytokine signal transduction inhibitor 2-antisense transcript 1 (IncRNA SOX21-AS1) in patients with brain glioma an...
lncRNA SOX21‐AS1migrationproliferationstemnessBreast cancer stem cells (BCSCs) have high tumorigenicity and invasiveness which contributes to recurrence and metastasis. The long nonヽoding RNA (LncRNA) SOX21〢S1 has been previously reported to modulate the properties of breast cancer stem cells via...
In addition, SOX21-AS1 depletion weakened the cell injury induced by MMP + . Moreover, SOX21-AS1 knockdown decreased Reactive Oxygen Species (ROS) generation and levels of TNF-伪, IL-1尾 and IL-6, but increased SOD activity. However, SOX21-AS1 up-regulation led to opposite results. ...
有淋巴结转移患者lncRNA SOX21-AS1相对表达水平升高(P<0.05).干扰lncRNA SOX21-AS1表达可抑制卵巢癌细胞增殖和转移能力,抑制Wnt/β-catenin信号通路活性并降低Wnt/β-catenin信号通路各蛋白的表达水平(P<0.05).结论 lncRNA SOX21-AS1在卵巢癌组织和细胞中高表达,干扰lncRNA SOX21-AS1的表达可抑制卵巢癌细胞增殖...